Type II Transmembrane Serine Proteases

被引：274

作者：

Bugge, Thomas H. ^{[1
]}

Antalis, Toni M. ^{[2
,3
]}

Wu, Qingyu ^{[4
,5
]}

机构：

[1] NIH, Proteases & Tissue Remodeling Sect, NIDCR, Bethesda, MD 20892 USA

[2] Univ Maryland, Sch Med, Ctr Vasc & Inflammatory Dis, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

[4] Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44195 USA

[5] Cleveland Clin, Lerner Res Inst, Dept Nephrol, Cleveland, OH 44195 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 35期

基金：

美国国家卫生研究院;

关键词：

HEPATOCYTE GROWTH-FACTOR; FACTOR ACTIVATOR INHIBITOR-1B; PROSTATE-CANCER PROGRESSION; EPITHELIAL SODIUM-CHANNEL; CELL-SURFACE; GENE FUSION; PLASMINOGEN-ACTIVATOR; MATRIPTASE-2; TMPRSS6; FUNCTIONAL-ANALYSIS; IRON-DEFICIENCY;

D O I：

10.1074/jbc.R109.021006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of genome and expressed sequence tag data bases at the turn of the millennium unveiled a new protease family named the type II transmembrane serine proteases (TTSPs) in a Journal of Biological Chemistry minireview (Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857-860). Since then, the number of known TTSPs has more than doubled, and more importantly, our understanding of the physiological functions of individual TTSPs and their contribution to human disease has greatly increased. Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field.

引用

页码：23177 / 23181

页数：5

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