A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey

被引：39

作者：

Oikonomidis, Lydia ^{[1
,2
]}

Santangelo, Andrea M. ^{[1
,2
]}

Shiba, Yoshiro ^{[1
,2
]}

Clarke, F. Hannah ^{[1
,2
]}

Robbins, Trevor W. ^{[2
,3
]}

Roberts, Angela C. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3DY, England

[2] Univ Cambridge, Behav & Clin Neurosci Inst, Downing St, Cambridge CB2 3EB, England

[3] Univ Cambridge, Dept Psychol, Downing St, Cambridge CB2 3EB, England

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2017年 / 77卷 / 03期

基金：

英国惠康基金;

关键词：

RDoc; marmoset; neuropsychiatric disorders; prefrontal cortex; OBSESSIVE-COMPULSIVE DISORDER; SPATIAL WORKING-MEMORY; VENTROLATERAL PREFRONTAL CORTEX; CARD SORTING TEST; GENERALIZED ANXIETY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PRIMATE ORBITOFRONTAL CORTEX; ORDERED SEQUENCING TASK; SET-SHIFTING ABILITY; SEROTONIN TRANSPORTER;

D O I：

10.1002/dneu.22446

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Some patients suffering from the same neuropsychiatric disorder may have no overlapping symptoms whilst others may share symptoms common to other distinct disorders. Therefore, the Research Domain Criteria initiative recognises the need for better characterisation of the individual symptoms on which to focus symptom-based treatment strategies. Many of the disorders involve dysfunction within the prefrontal cortex (PFC) and so the marmoset, due to their highly developed PFC and small size, is an ideal species for studying the neurobiological basis of the behavioural dimensions that underlie these symptoms.Here we focus on a battery of tests that address dysfunction spanning the cognitive (cognitive inflexibility and working memory), negative valence (fear generalisation and negative bias) and positive valence (anhedonia) systems pertinent for understanding disorders such as ADHD, Schizophrenia, Anxiety, Depression and OCD. Parsing the separable prefrontal and striatal circuits and identifying the selective neurochemical modulation (serotonin vs dopamine) that underlie cognitive dysfunction have revealed counterparts in the clinical domain. Aspects of the negative valence system have been explored both at individual- (trait anxiety and genetic variation in serotonin transporter) and circuit-based levels enabling the understanding of generalisation processes, negative biases and differential responsiveness to SSRIs. Within the positive valence system, the combination of cardiovascular and behavioural measures provides a framework for understanding motivational, anticipatory and consummatory aspects of anhedonia and their neurobiological mechanisms. Together, the direct comparison of experimental findings in marmosets with clinical studies is proving an excellent translational model to address the behavioural dimensions and neurobiology of neuropsychiatric symptoms. (c) 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 328-353, 2017

引用

页码：328 / 353

页数：26

共 275 条

[1]

ABBOTT DH, 1978, J REPROD FERTIL, V53, P155

[2]

Abbott DH, 2003, COMPARATIVE MED, V53, P339

[3] The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: A double dissociation experimental finding [J].