Targeting the indoleamine 2,3-dioxygenase pathway in cancer

被引：287

作者：

Moon, Yong Wha ^{[1
,2
]}

Hajjar, Joud ^{[3
]}

Hwu, Patrick ^{[4
]}

Naing, Aung ^{[2
]}

机构：

[1] CHA Univ, Dept Internal Med, CHA Bundang Med Ctr, Med Oncol, Songnam 463712, Gyeonggi Do, South Korea

[2] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Baylor Coll Med, Sect Immunol Allergy & Rheumatol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2015年 / 3卷

关键词：

Indoleamine 2,3-dioxygenase; IDO inhibitors; Immune surveillance; Immunomodulatory; Malignancy; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; DRAINING LYMPH-NODES; ARYL-HYDROCARBON RECEPTOR; MYELOID-LEUKEMIA CELLS; TRYPTOPHAN CATABOLISM; IMMUNE ACTIVATION; RESISTANCE MECHANISM; ENDOMETRIAL CANCER; COLORECTAL-CANCER;

D O I：

10.1186/s40425-015-0094-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.

引用

页数：10

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