Consensus best practice pathway of the UK Scleroderma Study Group: digital vasculopathy in systemic sclerosis

被引:97
作者
Hughes, Michael [1 ]
Ong, Voon H. [2 ]
Anderson, Marina E. [3 ]
Hall, Frances [4 ]
Moinzadeh, Pia [5 ]
Griffiths, Bridget [6 ]
Baildam, Eileen [7 ]
Denton, Christopher P. [2 ]
Herrick, Ariane L. [1 ]
机构
[1] Univ Manchester, Ctr Musculoskeletal Res, Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
[2] Royal Free Hosp, Ctr Rheumatol, London NW3 2QG, England
[3] Univ Liverpool, Inst Ageing & Chron Dis, Fac Hlth & Life Sci, Liverpool L69 3BX, Merseyside, England
[4] Cambridge Univ Hosp NHS Fdn Trust, Dept Rheumatol, Cambridge, England
[5] Univ Cologne, Dept Dermatol & Venereol, D-50931 Cologne, Germany
[6] Freeman Rd Hosp, Dept Rheumatol, Newcastle Upon Tyne, Tyne & Wear, England
[7] Alder Hey Childrens Fdn NHS Trust, Dept Paediat Rheumatol, Liverpool, Merseyside, England
关键词
systemic sclerosis; scleroderma; digital vasculopathy; Raynaud's phenomenon; digital ulcer; critical digital ischaemia; RAYNAUDS-PHENOMENON RESISTANT; CALCIUM-CHANNEL BLOCKERS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; VASCULAR-DISEASE; ULCERS; THERAPY; METAANALYSIS; MULTICENTER; SILDENAFIL;
D O I
10.1093/rheumatology/kev201
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Digital vasculopathy (comprising RP, digital ulceration and critical digital ischaemia) is responsible for much of the pain and disability experienced by patients with SSc. However, there is a limited evidence base to guide clinicians in the management of SSc-related digital vasculopathy. Our aim was to produce recommendations that would be helpful for clinicians, especially for those managing patients outside specialist centres. Methods. The UK Scleroderma Study Group set up several working groups to develop a number of consensus best practice pathways for the management of SSc-specific complications, including digital vasculopathy. Results. This overview presents the background and best practice consensus pathways for SSc-related RP, digital ulceration and critical ischaemia. Examples of drug therapies, including doses, are suggested in order to inform prescribing practice. Conclusion. A number of treatment algorithms are provided that are intended to provide the clinician with accessible reference tools for use in daily management.
引用
收藏
页码:2015 / 2024
页数:10
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