Regulation of Hemogenic Endothelial Cell Development and Function

被引：43
作者：
Wu, Yinyu [1 ,2 ,3 ]
Hirschi, Karen K. [1 ,2 ,3 ,4 ]
机构：
[1] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Genet, Yale Cardiovasc Res Ctr,Vasc Biol & Therapeut Pro, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06510 USA
[4] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA
来源：
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 | 2021年 / 83卷
关键词：
definitive hematopoiesis; hemogenic endothelial cell; endothelial cell specification; endothelial-to-hematopoietic transition; EHT; hematopoietic stem and progenitor cell; HSPC; HEMATOPOIETIC STEM-CELLS; C-MYB GENE; YOLK-SAC; DEFINITIVE HEMATOPOIESIS; NERVOUS-SYSTEM; RETINOIC ACID; TRANSCRIPTIONAL REGULATION; HAEMOGENIC ENDOTHELIUM; TARGETED DISRUPTION; AORTIC ENDOTHELIUM;
D O I：
10.1146/annurev-physiol-021119-034352
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells (HSPCs) essential for establishment and maintenance of the adult blood system. This process requires the specification of a subset of vascular endothelial cells to become blood-forming, or hemogenic, and the subsequent endothelial-to-hematopoietic transition to generate HSPCs therefrom. The mechanisms that regulate these processes are under intensive investigation, as their recapitulation in vitro from human pluripotent stem cells has the potential to generate autologous HSPCs for clinical applications. In this review, we provide an overview of hemogenic endothelial cell development and highlight the molecular events that govern hemogenic specification of vascular endothelial cells and the generation of multilineage HSPCs from hemogenic endothelium. We also discuss the impact of hemogenic endothelial cell development on adult hematopoiesis.
引用
收藏
页码：17 / 37
页数：21
相关论文
共 144 条
[81]   Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control [J].
Marcelo, Kathrina L. ;
Sills, Tiffany M. ;
Coskun, Suleyman ;
Vasavada, Hema ;
Sanglikar, Supriya ;
Goldie, Lauren C. ;
Hirschi, Karen K. .
DEVELOPMENTAL CELL, 2013, 27 (05) :504-515
[82]   Regulation of Endothelial Cell Differentiation and Specification [J].
Marcelo, Kathrina L. ;
Goldie, Lauren C. ;
Hirschi, Karen K. .
CIRCULATION RESEARCH, 2013, 112 (09) :1272-1287
[83]   HOMEOBOX GENES AND AXIAL PATTERNING [J].
MCGINNIS, W ;
KRUMLAUF, R .
CELL, 1992, 68 (02) :283-302
[84]   Smad1 and Smad5 differentially regulate embryonic hematopoiesis [J].
McReynolds, Lisa J. ;
Figueroa, Maria E. ;
Mullins, Mary C. ;
Evans, Todd .
BLOOD, 2007, 110 (12) :3881-3890
[85]   Definitive hematopoiesis is autonomously initiated by the AGM region [J].
Medvinsky, A ;
Dzierzak, E .
CELL, 1996, 86 (06) :897-906
[86]   MicroRNAs in hematopoietic development [J].
Montagner, Sara ;
Deho, Lorenzo ;
Monticelli, Silvia .
BMC IMMUNOLOGY, 2014, 15
[87]   Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells [J].
Monteiro, Rui ;
Pinheiro, Philip ;
Joseph, Nicola ;
Peterkin, Tessa ;
Koth, Jana ;
Repapi, Emmanouela ;
Bonkhofer, Florian ;
Kirmizitas, Arif ;
Patient, Roger .
DEVELOPMENTAL CELL, 2016, 38 (04) :358-370
[88]   A FUNCTIONAL C-MYB GENE IS REQUIRED FOR NORMAL MURINE FETAL HEPATIC HEMATOPOIESIS [J].
MUCENSKI, ML ;
MCLAIN, K ;
KIER, AB ;
SWERDLOW, SH ;
SCHREINER, CM ;
MILLER, TA ;
PIETRYGA, DW ;
SCOTT, WJ ;
POTTER, SS .
CELL, 1991, 65 (04) :677-689
[89]   Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation [J].
Mukai, Harumi Y. ;
Motohashi, Hozumi ;
Ohneda, Osamu ;
Suzuki, Norio ;
Nagano, Masumi ;
Yamamoto, Masayuki .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (21) :7953-7965
[90]   Phenotype and hematopoietic potential of side population cells throughout embryonic development [J].
Nadin, BM ;
Goodell, MA ;
Hirschi, KK .
BLOOD, 2003, 102 (07) :2436-2443
45678910111213