Regulation of Hemogenic Endothelial Cell Development and Function

被引：44

作者：

Wu, Yinyu ^{[1
,2
,3
]}

Hirschi, Karen K. ^{[1
,2
,3
,4
]}

机构：

[1] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Genet, Yale Cardiovasc Res Ctr,Vasc Biol & Therapeut Pro, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06510 USA

[4] Univ Virginia, Dept Cell Biol, Charlottesville, VA 22908 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 | 2021年 / 83卷

关键词：

definitive hematopoiesis; hemogenic endothelial cell; endothelial cell specification; endothelial-to-hematopoietic transition; EHT; hematopoietic stem and progenitor cell; HSPC; HEMATOPOIETIC STEM-CELLS; C-MYB GENE; YOLK-SAC; DEFINITIVE HEMATOPOIESIS; NERVOUS-SYSTEM; RETINOIC ACID; TRANSCRIPTIONAL REGULATION; HAEMOGENIC ENDOTHELIUM; TARGETED DISRUPTION; AORTIC ENDOTHELIUM;

D O I：

10.1146/annurev-physiol-021119-034352

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells (HSPCs) essential for establishment and maintenance of the adult blood system. This process requires the specification of a subset of vascular endothelial cells to become blood-forming, or hemogenic, and the subsequent endothelial-to-hematopoietic transition to generate HSPCs therefrom. The mechanisms that regulate these processes are under intensive investigation, as their recapitulation in vitro from human pluripotent stem cells has the potential to generate autologous HSPCs for clinical applications. In this review, we provide an overview of hemogenic endothelial cell development and highlight the molecular events that govern hemogenic specification of vascular endothelial cells and the generation of multilineage HSPCs from hemogenic endothelium. We also discuss the impact of hemogenic endothelial cell development on adult hematopoiesis.

引用

页码：17 / 37

页数：21

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