How T lymphocytes recognize lipid antigens

被引：12

作者：

De Libero, Gennaro ^{[1
]}

Mori, Lucia ^{[1
]}

机构：

[1] Univ Basel Hosp, Res Dept, CH-4031 Basel, Switzerland

来源：

FEBS LETTERS | 2006年 / 580卷 / 23期

关键词：

T-lymphocytes; antigen-presentation; CD1; lipid transfer proteins;

D O I：

10.1016/j.febslet.2006.08.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen-presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases. The immune system uses a variety of strategies to solubilise lipid antigens, to facilitate their internalization, processing, and loading on CD1 molecules. Recent studies in the field of lipid antigen presentation have revealed new mechanisms which allow the immune system to sense lipids as stimulatory antigens. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5580 / 5587

页数：8

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