How T lymphocytes recognize lipid antigens

被引：12

作者：

De Libero, Gennaro ^{[1
]}

Mori, Lucia ^{[1
]}

机构：

[1] Univ Basel Hosp, Res Dept, CH-4031 Basel, Switzerland

来源：

FEBS LETTERS | 2006年 / 580卷 / 23期

关键词：

T-lymphocytes; antigen-presentation; CD1; lipid transfer proteins;

D O I：

10.1016/j.febslet.2006.08.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen-presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases. The immune system uses a variety of strategies to solubilise lipid antigens, to facilitate their internalization, processing, and loading on CD1 molecules. Recent studies in the field of lipid antigen presentation have revealed new mechanisms which allow the immune system to sense lipids as stimulatory antigens. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：5580 / 5587

页数：8

相关论文

共 74 条

[1] Human CD1-restricted T cell recognition of lipids from pollens [J].

Agea, E ;

Russano, A ;

Bistoni, O ;

Mannucci, R ;

Nicoletti, I ;

Corazzi, L ;

Postle, AD ;

De Libero, G ;

Porcelli, SA ;

Spinozzi, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (02) :295-308

[2] A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan [J].

Amprey, JL ;

Im, JS ;

Turco, SJ ;

Murray, HW ;

Illarionov, PA ;

Besra, GS ;

Porcelli, SA ;

Späth, GF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (07) :895-904

[3] The cellular pathway of CD1e in immature and maturing dendritic cells [J].

Angénieux, C ;

Fraisier, V ;

Maître, B ;

Racine, V ;

van der Wel, N ;

Fricker, D ;

Proamer, F ;

Sachse, M ;

Cazenave, JP ;

Peters, P ;

Goud, B ;

Hanau, D ;

Sibarita, JB ;

Salamero, J ;

de la Salle, H .

TRAFFIC, 2005, 6 (04) :286-302

[4]

Battistini L, 1996, J NEUROIMMUNOL, V67, P145

[5] RECOGNITION OF A LIPID ANTIGEN BY CD1-RESTRICTED ALPHA-BETA(+) T-CELLS [J].

BEEKMAN, EM ;

PORCELLI, SA ;

MORITA, CT ;

BEHAR, SM ;

FURLONG, ST ;

BRENNER, MB .

NATURE, 1994, 372 (6507) :691-694

[6] Membrane specializations and endosome maturation in dendritic cells and B cells [J].

Boes, M ;

Cuvillier, A ;

Ploegh, H .

TRENDS IN CELL BIOLOGY, 2004, 14 (04) :175-183

[7] CD1: Antigen presentation and T cell function [J].

Brigl, M ;

Brenner, MB .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :817-890

[8] Intracellular trafficking pathway of newly synthesized CD1b molecules [J].

Briken, V ;

Jackman, RM ;

Dasgupta, S ;

Hoening, S ;

Porcelli, SA .

EMBO JOURNAL, 2002, 21 (04) :825-834

[9] CD1d function is regulated by microsomal triglyceride transfer protein [J].

Brozovic, S ;

Nagaishi, T ;

Yoshida, M ;

Betz, S ;

Salas, A ;

Chen, DH ;

Kaser, A ;

Glickman, J ;

Kuo, T ;

Little, A ;

Morrison, J ;

Corazza, N ;

Kim, JY ;

Colgan, SP ;

Young, SG ;

Exley, M ;

Blumberg, RS .

NATURE MEDICINE, 2004, 10 (05) :535-539

[10] Structural requirements for antigen presentation by mouse CD1 [J].

Burdin, N ;

Brossay, L ;

Degano, M ;

Iijima, H ;

Gui, M ;

Wilson, IA ;

Kronenberg, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10156-10161

← 1 2 3 4 5 6 7 8 →