Nitroketene acetal chemistry: efficient synthesis of 2-amino-3-nitro-4H-chromenes

被引：53

作者：

Rao, H. Surya Prakash ^{[1
]}

Geetha, K. ^{[1
]}

机构：

[1] Pondicherry Univ, Dept Chem, Pondicherry 605014, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 27期

关键词：

NMSM; 2-Hydroxybenzaldehydes; Michael addition; 4H-Chromenes; 2:1 adducts; APOPTOSIS INDUCERS; HTS ASSAY; 4-ARYL-4H-CHROMENES; DISCOVERY; DITHIOACETALS; HA-14-1; CANCER; SERIES; AGENTS;

D O I：

10.1016/j.tetlet.2009.04.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base-catalyzed reaction of the nitroketene N,S-acetals and the ring substituted 2-hydroxybenzaldehydes afforded a combinatorial library of the 2-alkylamino-3-nitro-4-alkylsulfanyl 4H-chromenes in excellent yields. Nucleophilic displacement of the C4 alkylsulfanyl group with different thiols afforded 4H-chromenes with structural diversity. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3836 / 3839

页数：4

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