Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

被引：9

作者：

Hynes-Smith, R. Willow ^{[1
,2
]}

Wittorf, Karli J. ^{[1
,2
]}

Buckley, Shannon M. ^{[1
,2
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE 68198 USA

来源：

TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 12期

基金：

美国国家卫生研究院;

关键词：

FBOX proteins; hematopoiesis; ubiquitin E3 ligases; ubiquitin proteasome system;

D O I：

10.1016/j.it.2020.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

引用

页码：1128 / 1140

页数：13

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