Estimating the age of the common ancestor of a sample of DNA sequences

被引：85
作者：
Fu, YX
Li, WH
机构：
[1] Human Genetics Center, University of Texas, Houston, TX
[2] Human Genetics Center, School of Public Health, University of Texas at Houston, Houston, TX 77225
来源：
MOLECULAR BIOLOGY AND EVOLUTION | 1997年 / 14卷 / 02期
关键词：
common ancestor; age estimation; coalescent approach; Y chromosome; Alu sequence;
D O I：
10.1093/oxfordjournals.molbev.a025753
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We present a simple Monte Carlo method for estimating the age of the most recent common ancestor (MRCA) of a sample of DNA sequences. We show that Templeton's (1993) estimator of the age of the MRCA based on the maximum number of nucleotide differences between two sequences in a sample is inaccurate, and we demonstrate the new method by reanalyzing a sample of DNA sequences from human Y chromosomes and a sample of human Alu sequences.
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页码：195 / 199
页数：5
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