Estimating the age of the common ancestor of a sample of DNA sequences

被引：87

作者：

Fu, YX

Li, WH

机构：

[1] Human Genetics Center, University of Texas, Houston, TX

[2] Human Genetics Center, School of Public Health, University of Texas at Houston, Houston, TX 77225

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 1997年 / 14卷 / 02期

关键词：

common ancestor; age estimation; coalescent approach; Y chromosome; Alu sequence;

D O I：

10.1093/oxfordjournals.molbev.a025753

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a simple Monte Carlo method for estimating the age of the most recent common ancestor (MRCA) of a sample of DNA sequences. We show that Templeton's (1993) estimator of the age of the MRCA based on the maximum number of nucleotide differences between two sequences in a sample is inaccurate, and we demonstrate the new method by reanalyzing a sample of DNA sequences from human Y chromosomes and a sample of human Alu sequences.

引用

页码：195 / 199

页数：5

共 13 条

[1]

Donnelly P, 1996, SCIENCE, V272, P1357, DOI 10.1126/science.272.5266.1357

[2] ABSENCE OF POLYMORPHISM AT THE ZFY LOCUS ON THE HUMAN Y-CHROMOSOME [J].