Long-term cortical synaptic changes contribute to chronic pain and emotional disorders

被引:27
作者
Zhuo, Min [1 ,2 ,3 ,4 ]
机构
[1] Xi An Jiao Tong Univ, Frontier Inst Sci, Ctr Neuron & Dis, Xian 710049, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Frontier Inst Technol, Ctr Neuron & Dis, Xian 710049, Shaanxi, Peoples R China
[3] Univ Toronto, Fac Med, Dept Physiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[4] Univ Toronto, Ctr Study Pain, Toronto, ON M5S 1A8, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Anterior cingulate cortex; LTP; Pain; Chronic pain; Anxiety; Insular cortex; AMPA receptor; NMDA receptor; AC1; Mice; ANTERIOR CINGULATE CORTEX; NEUROPATHIC PAIN; BEHAVIORAL SENSITIZATION; POTENTIATION; RECEPTOR; MECHANISMS; PLASTICITY; HYPERACTIVITY; NEURONS; ANXIETY;
D O I
10.1016/j.neulet.2018.11.048
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Increasing evidence consistently indicates that cortical mechanisms play important roles in chronic pain and its emotional disorders. Central synapses, especially excitatory synapses, are undergoing long-term memory-like plastic changes after peripheral injury. These changes not only occur at the single synaptic level, but also take place at cortical and subcortical circuits. Consequently, neuronal responses to peripheral sensory stimuli, or even to sensory inputs triggered by normal physiological signals such as touch and movement, are significantly potentiated or increased. Such prolonged cortical excitation likely contributes to chronic pain and its related emotional changes. In this short review article, I will summarize recent progress using animal models and explore possible different mechanisms that may contribute to chronic pain in the brain.
引用
收藏
页码:66 / 70
页数:5
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