Response of Dental Pulp Stem Cells to Synthetic, Allograft, and Xenograft Bone Scaffolds

被引：24

作者：

Motamedian, Saeed Reza ^{[1
]}

Tabatabaei, Fahime Sadat ^{[2
]}

Akhlaghi, Fahimeh ^{[3
]}

Torshabi, Maryam ^{[2
]}

Gholamin, Parisan ^{[4
]}

Khojasteh, Arash ^{[3
,5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Orthodont, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Dent Mat, Sch Dent, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Dent, Dept Oral & Maxillofacial Surg, Daneshjou Blvd, Tehran 19839, Iran

[4] Shahid Sadoughi Univ Med Sci, Dept Periodont, Yazd, Iran

[5] Univ Antwerp, Sch Med, Antwerp, Belgium

来源：

INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY | 2017年 / 37卷 / 01期

关键词：

IN-VITRO; TRICALCIUM PHOSPHATE; CANCELLOUS BONE; NATURAL BONE; DIFFERENTIATION; GROWTH; AUGMENTATION; OSTEOBLASTS; GRAFTS; BIOMATERIALS;

D O I：

10.11607/prd.2121

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Different degrees of clinical success have been reported for synthetic, allograft, and xenograft bone substitutes in human trials. Although these substitutes have been clinically investigated, their in vitro effects on cell differentiation remain unclear. Proliferation, differentiation, and attachment of dental pulp stem cells (DPSCs) to 3-tricalcium phosphate (3-TCP), freeze-dried bone allograft (FDBA), and deproteinized bovine bone mineral (DBBM) were compared in this study. M-T assay, measurement of total DNA, and reverse transcriptase polymerase chain reaction were performed. 1-TCP had the highest potential for DPSC attachment and proliferation, while FDBA induced osteoblastic differentiation of DPSCs. Further in vivo investigations are necessary to select a clinically appropriate scaffold.

引用

页码：49 / 59

页数：11

共 40 条

[1] Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: A preliminary report [J].

Behnia, Hossein ;

Khojasteh, Arash ;

Soleimani, Masoud ;

Tehranchi, Azita ;

Atashi, Amir .

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2012, 40 (01) :2-7

[2] Secondary repair of alveolar clefts using human mesenchymal stem cells [J].

Behnia, Hossein ;

Khojasteh, Arash ;

Soleimani, Masoud ;

Tehranchi, Azita ;

Khoshzaban, Ahad ;

Keshel, Saeed Hidari ;

Atashi, Reza .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2009, 108 (02) :E1-E6

[3] Comparative evaluation of different calcium phosphate-based bone graft granules an in vitro study with osteoblast-like cells [J].

Bernhardt, Anne ;

Lode, Anja ;

Peters, Fabian ;

Gelinsky, Michael .

CLINICAL ORAL IMPLANTS RESEARCH, 2013, 24 (04) :441-449

[4] Novel ceramic bone replacement material Osbone® in a comparative in vitro study with osteoblasts [J].

Bernhardt, Anne ;

Lode, Anja ;

Peters, Fabian ;

Gelinsky, Michael .

CLINICAL ORAL IMPLANTS RESEARCH, 2011, 22 (06) :651-657

[5]

Bowers K T, 1992, Int J Oral Maxillofac Implants, V7, P302

[6] FREEZE-DRIED ALLOGENEIC SEGMENTAL CORTICAL-BONE GRAFTS IN DOGS [J].

BURCHARDT, H ;

GLOWCZEWSKIE, F ;

RUDNER, C ;

ENNEKING, WF ;

JONES, H .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1978, 60 (08) :1082-1090

[7] CLINICAL EVALUATION OF FREEZE-DRIED BONE GRAFTS [J].

CARR, CR ;

HYATT, GW .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1955, 37 (03) :549-&

[8] Osteonectin-null mutation compromises osteoblast formation, maturation, and survival [J].

Delany, AM ;

Kalajzic, I ;

Bradshaw, AD ;

Sage, EH ;

Canalis, E .

ENDOCRINOLOGY, 2003, 144 (06) :2588-2596

[9]

EGGLI PS, 1988, CLIN ORTHOP RELAT R, P127

[10]

Eslaminejad MB, 2008, YAKHTEH, V10, P205

← 1 2 3 4 →