Release of salicylic acid through poly(vinyl alcohol/poly(vinyl pyrrolidone) and poly(vinyl alcohol-g-N-vinyl-2-pyrrolidone) membranes

被引：13

作者：

Sanli, Oya ^{[1
]}

Orhan, Emel ^{[1
]}

Asman, Gulsen ^{[1
]}

机构：

[1] Gazi Univ, Fen Edebiyat Fak, TR-06500 Ankara, Turkey

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2006年 / 102卷 / 02期

关键词：

salicylic acid; membrane; drug delivery systems; transdermal; blends;

D O I：

10.1002/app.24453

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A controlled release profile of salicylic acid (SA) for transdermal administration has been developed. Poly (vinyl alcohol) (PVA) and Poly(vinyl alcohol)/Poly (vinyl pyrrolidone) (PVP) blended preparations were used to prepare the membranes by solvent-casting technique. The release of the drug from the membranes was evaluated at in vitro conditions. The effects of PVA/PVP (v/v) ratio, pH, SA concentration and temperature were investigated. 60/40 (v/v) PVA/PVP ratio was found to be the best ratio for the SA release. Increase in pH and temperature was observed to increase the transport of SA. Instead of blending PVA with PVP, N-Vinyl-2-pyrrolidone (VP) was grafted onto the PVA and the delivery performance for SA was compared with that of the blended PVA/PVP membranes. Grafted membranes gave higher transport percentages than the blended membranes. (c) 2006 Wiley Periodicals, Inc.

引用

页码：1244 / 1253

页数：10

共 41 条

[1] Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blends: Miscibility, microheterogeneity and free volume change [J].