Heterocycles from α-Aminonitriles

被引：75
作者：
Otto, Nicola [1 ]
Opatza, Till [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 41期
关键词：
alpha-aminonitriles; heterocycles; nitrogen heterocycles; synthetic methods; ONE-POT SYNTHESIS; ASYMMETRIC NUCLEOPHILIC ACYLATION; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; 1,3-DIPOLAR CYCLOADDITION REACTIONS; ACYL ANION EQUIVALENTS; CHIRAL AMINO NITRILES; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CN(R; S); METHOD; POLYSUBSTITUTED PYRROLIDINES;
D O I：
10.1002/chem.201403956
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Owing to their various modes of reactivity, alpha-aminonitriles represent versatile building blocks for the construction of a wide range of nitrogen heterocycles. The present Concept article focuses on synthetic methodologies using their bifunctional nature which is the basis of their reactivity as alpha-amino carbanions and as iminium ions. Reactions exclusively taking place on either the amine or on the nitrile moiety will not be considered.
引用
收藏
页码：13064 / 13077
页数：14
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