Heterocycles from α-Aminonitriles

被引：75

作者：

Otto, Nicola ^{[1
]}

Opatza, Till ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, Mainz, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 41期

关键词：

alpha-aminonitriles; heterocycles; nitrogen heterocycles; synthetic methods; ONE-POT SYNTHESIS; ASYMMETRIC NUCLEOPHILIC ACYLATION; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; 1,3-DIPOLAR CYCLOADDITION REACTIONS; ACYL ANION EQUIVALENTS; CHIRAL AMINO NITRILES; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CN(R; S); METHOD; POLYSUBSTITUTED PYRROLIDINES;

D O I：

10.1002/chem.201403956

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Owing to their various modes of reactivity, alpha-aminonitriles represent versatile building blocks for the construction of a wide range of nitrogen heterocycles. The present Concept article focuses on synthetic methodologies using their bifunctional nature which is the basis of their reactivity as alpha-amino carbanions and as iminium ions. Reactions exclusively taking place on either the amine or on the nitrile moiety will not be considered.

引用

页码：13064 / 13077

页数：14

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