Hereditary ovarian carcinomas: clinico-biological features and treatment

被引：4

作者：

Floquet, Anne ^{[1
]}

Stoeckle, Eberhard ^{[2
]}

Croce, Sabrina ^{[3
]}

Longy, Michel ^{[4
]}

Mc Grogan, Gaetan ^{[3
]}

Barouk, Emmanuelle ^{[4
]}

Bubien, Virginie ^{[4
]}

Garbay, Delphine ^{[1
]}

Joly, Eglantine ^{[4
]}

Guyon, Frederic ^{[2
]}

机构：

[1] Inst Bergonie, Dept Med Oncol, F-33076 Bordeaux, France

[2] Inst Bergonie, Dept Chirurg, F-33076 Bordeaux, France

[3] Inst Bergonie, Dept Anatomopathol, F-33076 Bordeaux, France

[4] Inst Bergonie, Unite Oncogenet, F-33076 Bordeaux, France

来源：

BULLETIN DU CANCER | 2014年 / 101卷 / 02期

关键词：

hereditary ovarian cancer; hereditary breast ovarian cancer; Lynch syndrom; Parp inhibitors; EPITHELIAL OVARIAN; BRCA2; MUTATIONS; POLYMERASE INHIBITOR; CANCER; SURVIVAL; WOMEN; RESISTANCE; OLAPARIB; THERAPY; BREAST;

D O I：

10.1684/bdc.2014.1888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hereditary ovarian cancers account for 10% of all cases. Two major syndromes with dominant autosomal transmission are identified. The most common one is breast-ovarian cancer syndrome due to BRCA1 and BRCA2 genes mutations, and the Lynch syndrome with mutated MMR genes is the other. Alterations in homologous recombination specifically observed in ovarian cancer with BRCA defects associated to Parp inhibition create a synthetic lethality of special interest. Numerous studies are in progress to explore this promising new approach. Furthermore, it seems that carcinogenesis of these two syndromes are different, suggesting alternative therapeutic options in the near future in order to improve prognosis of ovarian carcinomas.

引用

页码：167 / 174

页数：8

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