Development of β-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy

被引:56
作者
Bertin, E
Gangnerau, MN
Bellon, G
Bailbé, D
De Vacqueur, AA
Portha, B
机构
[1] Univ Paris 07, CNRS, UMR 7059, Lab Physiopathol Nutr, F-75251 Paris 05, France
[2] Ctr Rech Merck Lipha, F-91385 Chilly Mazarin, France
[3] Hop Robert Debre, Biochim Lab, F-51092 Reims, France
关键词
endocrine pancreas;
D O I
10.1152/ajpregu.00037.2002
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Fetal malnutrition is now proposed as a risk factor of later obesity and type II diabetes. We previously analyzed the long-term impact of reduced protein and/or energy intake strictly limited to the last week of pregnancy in Wistar rats. Three protocols of gestational malnutrition were used: 1) low-protein isocaloric diet (5 instead of 15%) with pair feeding to the mothers receiving the control diet, 2) restricted diet (50% of control diet), and 3) low protein-restricted diet (50% of low-protein diet). Only isolated protein restriction induced a long-term beta-cell mass decrease. In the present study, we used the same protocols of food restriction to analyze their short-term impact (on day 21.5 of pregnancy) on beta-cell mass development. A 50% beta-cell mass decrease was present in the three restricted groups, but low-protein diet, either associated or not to energy restriction, increased fetal beta-cell insulin content. Among all the parameters analyzed to further explain our results, we found that the fetal plasma level of taurine was lowered by low-protein diet and was the main predictor of the fetal plasma insulin level (r = 0.63, P < 0.01). In conclusion, rat fetuses exposed to protein and/or energy restriction during the third part of pregnancy have a similar dramatic decrease in beta-cell mass, and their ability to recover beta-cell mass development retardation depends on the type of malnutrition used. Moreover, our results support the hypothesis that taurine might play an important role in fetal beta-cell mass function.
引用
收藏
页码:R623 / R630
页数:8
相关论文
共 42 条
  • [1] Contrasted impact of maternal rat food restriction on the fetal endocrine pancreas
    Alvarez, C
    Martin, MA
    Goya, L
    Bertin, E
    Portha, B
    PascualLeone, AM
    [J]. ENDOCRINOLOGY, 1997, 138 (06) : 2267 - 2273
  • [2] ALVAREZ E, 1986, DIABETES METAB, V12, P337
  • [3] The indispensability of dispensable indexes
    Bertino, E
    Ooi, BC
    [J]. IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING, 1999, 11 (01) : 17 - 27
  • [4] MATERNAL NUTRITION AND PRENATAL GROWTH - EXPERIMENTAL STUDIES OF EFFECTS OF MATERNAL UNDERNUTRITION ON FETAL AND PLACENTAL GROWTH
    BRASEL, JA
    WINICK, M
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1972, 47 (254) : 479 - &
  • [5] Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances
    Byberg, L
    McKeigue, PM
    Zethelius, B
    Lithell, HO
    [J]. DIABETOLOGIA, 2000, 43 (01) : 54 - 60
  • [6] Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet
    Cherif, H
    Reusens, B
    Ahn, MT
    Hoet, JJ
    Remacle, C
    [J]. JOURNAL OF ENDOCRINOLOGY, 1998, 159 (02) : 341 - 348
  • [7] A protein-restricted diet during pregnancy alters in vitro insulin secretion from islets of fetal Wistar rats
    Cherif, H
    Reusens, B
    Dahri, S
    Remacle, C
    [J]. JOURNAL OF NUTRITION, 2001, 131 (05) : 1555 - 1559
  • [8] ASSOCIATION OF LOW-BIRTH-WEIGHT WITH BETA-CELL FUNCTION IN THE ADULT 1ST DEGREE RELATIVES OF NON-INSULIN-DEPENDENT DIABETIC SUBJECTS
    COOK, JTE
    LEVY, JC
    PAGE, RCL
    SHAW, JAG
    HATTERSLEY, AT
    TURNER, RC
    [J]. BRITISH MEDICAL JOURNAL, 1993, 306 (6873) : 302 - 306
  • [9] Birth weight and adult hypertension and obesity in women
    Curhan, GC
    Chertow, GM
    Willett, WC
    Spiegelman, D
    Colditz, GA
    Manson, JE
    Speizer, FE
    Stampfer, MJ
    [J]. CIRCULATION, 1996, 94 (06) : 1310 - 1315
  • [10] Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
    Curhan, GC
    Willett, WC
    Rimm, EB
    Spiegelman, D
    Ascherio, AL
    Stampfer, MJ
    [J]. CIRCULATION, 1996, 94 (12) : 3246 - 3250