Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight

被引:582
作者
Lang, T
LeBlanc, A
Evans, H
Lu, Y
Genant, H
Yu, A
机构
[1] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[3] Univ Space Res Assoc, Life Sci Div, Houston, TX USA
[4] Wyle Labs, Houston, TX USA
关键词
spaceflight; bone QCT; bone densitometry; osteoporosis; mechanical loading;
D O I
10.1359/JBMR.040307
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We measured cortical and trabecular bone loss using QCT of the spine and hip in 14 crewmembers making 4- to 6-month flights on the International Space Station. There was no compartment-specific loss of bone in the spine. Cortical bone mineral loss in the hip occurred primarily by endocortical thinning.
引用
收藏
页码:1006 / 1012
页数:7
相关论文
共 19 条
  • [1] Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT)
    Augat, P
    Gordon, CL
    Lang, TF
    Iida, H
    Genant, HK
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (10) : 2873 - 2883
  • [2] Morphological and structural characteristics of the proximal femur in human and rat
    Bagi, CM
    Wilkie, D
    Georgelos, K
    Williams, D
    Bertolini, D
    [J]. BONE, 1997, 21 (03) : 261 - 267
  • [3] Structural adaptation to changing skeletal load in the progression toward hip fragility: The study of osteoporotic fractures
    Beck, TJ
    Oreskovic, TL
    Stone, KL
    Ruff, CB
    Ensrud, K
    Nevitt, MC
    Genant, HK
    Cummings, SR
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (06) : 1108 - 1119
  • [4] Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats
    Bloomfield, SA
    Allen, MR
    Hogan, HA
    Delp, MD
    [J]. BONE, 2002, 31 (01) : 149 - 157
  • [5] CALCULATION OF CROSS-SECTIONAL GEOMETRY OF BONE FROM CT IMAGES WITH APPLICATION IN POSTMENOPAUSAL WOMEN
    CORCORAN, TA
    SANDLER, RB
    MYERS, ER
    LEBOWITZ, HH
    HAYES, WC
    [J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1994, 18 (04) : 626 - 633
  • [6] Bone mineral density in upper and lower extremities during 12 months after spinal cord injury measured by peripheral quantitative computed tomography
    Frey-Rindova, P
    de Bruin, ED
    Stüssi, E
    Dambacher, MA
    Dietz, V
    [J]. SPINAL CORD, 2000, 38 (01) : 26 - 32
  • [7] Hans D, 1998, Rev Rhum Engl Ed, V65, P489
  • [8] CORRELATIONS BETWEEN ORTHOGONAL MECHANICAL-PROPERTIES AND DENSITY OF TRABECULAR BONE - USE OF DIFFERENT DENSITOMETRIC MEASURES
    KEYAK, JH
    LEE, IY
    SKINNER, HB
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (11): : 1329 - 1336
  • [9] Volumetric quantitative computed tomography of the proximal femur: Precision and relation to bone strength
    Lang, TF
    Keyak, JH
    Heitz, MW
    Augat, P
    Lu, Y
    Mathur, A
    Genant, HK
    [J]. BONE, 1997, 21 (01) : 101 - 108
  • [10] Assessment of vertebral bone mineral density using volumetric quantitative CT
    Lang, TF
    Li, J
    Harris, ST
    Genant, HK
    [J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1999, 23 (01) : 130 - 137