SYNTHESIS, FUNGICIDAL AND ANTIBACTERIAL ACTIVITY OF NEW PYRIDAZINE DERIVATIVES

被引：13

作者：

Foks, Henryk ^{[1
]}

Wisterowicz, Krystyna ^{[1
]}

Miszke, Agnieszka ^{[1
]}

Brozewicz, Kamil ^{[1
]}

Wisniewska, Katarzyna ^{[2
]}

Dabrowska-Szponar, Maria ^{[2
]}

机构：

[1] Med Univ Gdansk, Dept Organ Chem, Gdansk, Poland

[2] Med Univ Gdansk, Dept Med Microbiol, Gdansk, Poland

来源：

HETEROCYCLES | 2009年 / 78卷 / 04期

关键词：

Thiopyridazine; Thioamide; Antibacterial Activity; Ammonium Polysulfide; Hydrazinylpyridazine; INTERLEUKIN-1-BETA IL-1-BETA PRODUCTION; BIOLOGICAL EVALUATION; 1,4-DIAZINE DERIVATIVES; CARBOXYLIC-ACIDS; INHIBITORS; BIOACTIVITIES; 1,3-DIAZINE; 1,2-DIAZINE; RECEPTOR; LIGANDS;

D O I：

10.3987/COM-08-11577

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compounds 1 - 3 were obtained in the reaction of 3,6-dichloropyridazines with phenylacetonitriles in the biphasic system - DMSO / 50% NaOH. The chlorine atom was replaced with cycloalkylamino (4 - 13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25 - 34). Pyridazynylphenylacetonitriles were converted into amides 14 - 18 and thioamides 19 - 22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1 - 17, 19 43 were screened for antibacterial and fungicidal activities.

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页码：961 / 975

页数：15

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