Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

被引：67

作者：

Matsumoto, Rae R. ^{[1
,2
]}

Seminerio, Michael J. ^{[1
,3
]}

Turner, Ryan C. ^{[2
,4
]}

Robson, Matthew J. ^{[1
,5
]}

Nguyen, Linda ^{[1
,2
]}

Miller, Diane B. ^{[6
]}

O'Callaghan, James P. ^{[6
]}

机构：

[1] W Virginia Univ, Sch Pharm, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA

[2] W Virginia Univ, Sch Med, Ctr Neurosci, Morgantown, WV 26506 USA

[3] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[4] W Virginia Univ, Sch Med, Dept Neurosurg, Morgantown, WV 26506 USA

[5] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA

[6] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Morgantown, WV 26505 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2014年 / 144卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Autonomic nervous system; Hyperthermia; Methamphetamine; Reactive oxygen species; Thermoregulation; Toxicity; INDUCED DOPAMINERGIC NEUROTOXICITY; SIGMA-RECEPTOR ANTAGONIST; HEAT-SHOCK-PROTEIN; BODY-TEMPERATURE; BRAIN HYPERTHERMIA; STRIATAL DOPAMINE; MESSENGER-RNA; THERMOREGULATORY RESPONSES; ENVIRONMENTAL-TEMPERATURE; SUBSTITUTED AMPHETAMINES;

D O I：

10.1016/j.pharmthera.2014.05.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：28 / 40

页数：13

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