The genetic and epigenetic landscape of early-onset colorectal cancer

被引：15

作者：

Boland, C. Richard ^{[1
]}

Goel, Ajay ^{[2
,3
]}

Patel, Swati G. ^{[4
]}

机构：

[1] Univ Calif San Diego, Sch Med, Med, La Jolla, CA 92093 USA

[2] City Hope Comprehens Canc Ctr, Beckman Res Inst, Dept Mol Diagnost & Expt Therapeut, Monrovia, CA 91016 USA

[3] City Hope Comprehens Canc Ctr, Beckman Res Inst, Biotech Innovat, Monrovia, CA 91016 USA

[4] Univ Colorado, Sch Med, Rocky Mt Reg Vet Affairs Med Ctr, Med Gastroenterol, Aurora, CO USA

来源：

COLORECTAL CANCER | 2020年 / 9卷 / 03期

关键词：

early-onset colorectal cancer; epigenetics; familial cancer; genetics; LINE-1; hypomethylation; Lynch syndrome; MISMATCH-REPAIR DEFICIENCY; MICROSATELLITE INSTABILITY; YOUNG-PATIENTS; LYNCH SYNDROME; HEREDITARY; MUTATIONS; FEATURES; PREVALENCE; GERMLINE; CRITERIA;

D O I：

10.2217/crc-2020-0005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) in individuals under the age of 50 is a problem that is increasing in USA and around the world. In this review, we discuss the degree to which early-onset (EO)CRC may be due to unsuspected Lynch syndrome or other inherited germline variants that predispose to cancer, describe the known somatic genetic alterations in EO tumors and discuss alterations in DNA methylation. Approximately 20% of EOCRCs can be attributed to identifiable germline mutations in genes that cause familial cancer syndromes. A variety of other genetic/epigenetic alterations have also been reported. We conclude that this is a heterogeneous problem, that requires a comprehensive analysis of genetic/epigenetic signatures to better understand EOCRC. Various subsets of EOCRCs must be analyzed individually for clues regarding the etiologies and possible specific therapies for this disease.

引用

页数：14

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