Characterization of biologically inactive spirolides E and F: Identification of the spirolide pharmacophore

被引：126

作者：

Hu, TM ^{[1
]}

Curtis, JM ^{[1
]}

Walter, JA ^{[1
]}

Wright, JLC ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,INST MARINE BIOSCI,HALIFAX,NS B3H 3Z1,CANADA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 43期

关键词：

D O I：

10.1016/0040-4039(96)01721-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new spirolide derivatives, E and F, have been isolated in low yield from shellfish extracts. Absence of activity in the mouse bioassay of these derivatives, and of the secondary amine reduction product of spirolide B, identifies the spirolide pharmacophore as the cyclic imine moiety. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7671 / 7674

页数：4

共 7 条

[1]

Falk M, 1996, J COMPUT CHEM, V17, P409, DOI 10.1002/(SICI)1096-987X(199603)17:4<409::AID-JCC3>3.0.CO

[2]

2-Y

[3]

HU T, 1996, IN PRESS J NAT PROD

[4] SPIROLIDE-B AND SPIROLIDE-D, 2 NOVEL MACROCYCLES ISOLATED FROM THE DIGESTIVE GLANDS OF SHELLFISH [J].

HU, TM ;

CURTIS, JM ;

OSHIMA, Y ;

QUILLIAM, MA ;

WALTER, JA ;

WATSONWRIGHT, WM ;

WRIGHT, JLC .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (20) :2159-2161

[5] GYMNODIMINE, A NEW MARINE TOXIN OF UNPRECEDENTED STRUCTURE ISOLATED FROM NEW-ZEALAND OYSTERS AND THE DINOFLAGELLATE, GYMNODINIUM SP [J].

SEKI, T ;

SATAKE, M ;

MACKENZIE, L ;

KASPAR, HF ;

YASUMOTO, T .

TETRAHEDRON LETTERS, 1995, 36 (39) :7093-7096

[6] PROROCENTROLIDE, A TOXIC NITROGENOUS MACROCYCLE FROM A MARINE DINOFLAGELLATE, PROROCENTRUM-LIMA [J].

TORIGOE, K ;

MURATA, M ;

YASUMOTO, T ;

IWASHITA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (23) :7876-7877

[7] PINNATOXIN-A - A TOXIC AMPHOTERIC MACROCYCLE FROM THE OKINAWAN BIVALVE PINNA-MURICATA [J].

UEMURA, D ;

CHOU, T ;

HAINO, T ;

NAGATSU, A ;

FUKUZAWA, S ;

ZHENG, SZ ;

CHEN, HS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (03) :1155-1156

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