Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus

被引：22

作者：

Vega-Rua, Anubis ^{[1
]}

Schmitt, Christine ^{[2
]}

Bonne, Isabelle ^{[2
]}

Locker, Jacomine Krijnse ^{[2
]}

Failloux, Anna-Bella ^{[1
]}

机构：

[1] Inst Pasteur, Arboviruses & Insect Vectors Unit, Dept Virol, F-75724 Paris 15, France

[2] Inst Pasteur, Ctr Innovat & Technol Res, Ultrapole, F-75724 Paris 15, France

来源：

VIRUSES-BASEL | 2015年 / 7卷 / 11期

关键词：

Chikungunya virus; Aedes albopictus; salivary glands; budding; replication; transmission electron microscopy; VECTOR COMPETENCE; INFECTION; TRANSMISSION;

D O I：

10.3390/v7112917

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands.

引用

页码：5902 / 5907

页数：6

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