Therapeutic Efficacy of Leukocytapheresis in a Pregnant Woman with Refractory Adult-onset Still's Disease

被引：9

作者：

Odai, Tsuyoshi ^{[1
]}

Isozaki, Takeo ^{[2
]}

Kasama, Tsuyoshi ^{[2
]}

Ogata, Hiroaki ^{[3
]}

Kinugasa, Eriko ^{[3
]}

机构：

[1] Ebina Gen Hosp, Div Gen Internal Med, Ebina, Kanagawa, Japan

[2] Showa Univ, Sch Med, Dept Med, Div Rheumatol, Shinagawa, Japan

[3] Showa Univ, Northern Yokohama Hosp, Dept Internal Med, Yokohama, Kanagawa, Japan

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 17期

关键词：

leukocytapheresis; adult-onset Still's disease; pregnancy; refractory; TUMOR-NECROSIS-FACTOR; ULCERATIVE-COLITIS; RHEUMATOID-ARTHRITIS; CYTOKINE LEVELS; MULTICENTER; GRANULOCYTE; APHERESIS; DELIVERY; AGENTS; FLUID;

D O I：

10.2169/internalmedicine.54.4271

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is the first report of the efficacy of leukocytapheresis (LCAP) in a patient with refractory adult onset Still's disease (AOSD) during pregnancy. A 32-year-old Chinese pregnant woman with AOSD who had been treated with prednisolone failed to achieve disease stabilization. The patient's disease was successfully controlled with the initiation of LCAP. Subsequently, she gave birth via Caesarean section to a 1,878 g baby boy at 34 weeks of gestation while maintaining remission. We conclude that LCAP is an alternative treatment in pregnant patients with refractory AOSD, particularly in those concerned about potential teratogenic and other adverse effects.

引用

页码：2261 / 2266

页数：6

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