The emerging role of serum/glucocorticoid-regulated kinases in cancer

被引：8
作者：
Castel, Pau [1 ]
Scaltriti, Maurizio [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, HOPP, 1275 York Ave,Box 20, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
来源：
CELL CYCLE | 2017年 / 16卷 / 01期
关键词：
AKT; drug resistance; mTORC1; PI3K inhibitors; PIK3CA; SGK1; TSC2; INHIBITION; RESISTANCE; ACTIVATION; MTORC1; SERUM; SGK1;
D O I：
10.1080/15384101.2016.1232071
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：5 / 6
页数：2
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  • [1] The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumourgrowth
    Bago, Ruzica
    Sommer, Eeva
    Castel, Pau
    Crafter, Claire
    Bailey, Fiona P.
    Shpiro, Natalia
    Baselga, Jose
    Cross, Darren
    Eyers, Patrick A.
    Alessi, Dario R.
    [J]. EMBO JOURNAL, 2016, 35 (17) : 1902 - 1922
  • [2] PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
    Castel, Pau
    Ellis, Haley
    Bago, Ruzica
    Toska, Eneda
    Razavi, Pedram
    Carmona, F. Javier
    Kannan, Srinivasaraghavan
    Verma, Chandra S.
    Dickler, Maura
    Chandarlapaty, Sarat
    Brogi, Edi
    Alessi, Dario R.
    Baselga, Jose
    Scaltriti, Maurizio
    [J]. CANCER CELL, 2016, 30 (02) : 229 - 242
  • [3] mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    Garcia-Martinez, Juan M.
    Alessi, Dario R.
    [J]. BIOCHEMICAL JOURNAL, 2008, 416 : 375 - 385
  • [4] SGK kinases and their role in epithelial transport
    Loffing, J
    Flores, SY
    Staub, O
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2006, 68 : 461 - 490
  • [5] Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
    Sommer, Eeva M.
    Dry, Hannah
    Cross, Darren
    Guichard, Sylvia
    Davies, Barry R.
    Alessi, Dario R.
    [J]. BIOCHEMICAL JOURNAL, 2013, 452 : 499 - 508
  • [6] AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
    Vasudevan, Krishna M.
    Barbie, David A.
    Davies, Michael A.
    Rabinovsky, Rosalia
    McNear, Chontelle J.
    Kim, Jessica J.
    Hennessy, Bryan T.
    Tseng, Hsiuyi
    Pochanard, Panisa
    Kim, So Young
    Dunn, Ian F.
    Schinzel, Anna C.
    Sandy, Peter
    Hoersch, Sebastian
    Sheng, Qing
    Gupta, Piyush B.
    Boehm, Jesse S.
    Reiling, Jan H.
    Silver, Serena
    Lu, Yiling
    Stemke-Hale, Katherine
    Dutta, Bhaskar
    Joy, Corwin
    Sahin, Aysegul A.
    Gonzalez-Angulo, Ana Maria
    Lluch, Ana
    Rameh, Lucia E.
    Jacks, Tyler
    Root, David E.
    Lander, Eric S.
    Mills, Gordon B.
    Hahn, William C.
    Sellers, William R.
    Garraway, Levi A.
    [J]. CANCER CELL, 2009, 16 (01) : 21 - 32
  • [7] CHARACTERIZATION OF SGK, A NOVEL MEMBER OF THE SERINE THREONINE PROTEIN-KINASE GENE FAMILY WHICH IS TRANSCRIPTIONALLY INDUCED BY GLUCOCORTICOIDS AND SERUM
    WEBSTER, MK
    GOYA, L
    GE, Y
    MAIYAR, AC
    FIRESTONE, GL
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (04) : 2031 - 2040
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