Roles of lndole as an Interspecies and Interkingdom Signaling Molecule

被引：386

作者：

Lee, Jin-Hyung ^{[1
]}

Wood, Thomas K. ^{[2
]}

Lee, Jintae ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Kyongsan 712749, South Korea

[2] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA

来源：

TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

O157/H7 BIOFILM FORMATION; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; GUT MICROBIOTA; INDOLE; BACTERIA; GROWTH; TRYPTOPHANASE; RESISTANCE; EXPRESSION;

D O I：

10.1016/j.tim.2015.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior. This review presents current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems.

引用

页码：707 / 718

页数：12

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