Emerging Roles for Anionic Non-Bilayer Phospholipids in Fortifying the Outer Membrane Permeability Barrier

被引：15

作者：

Bishop, Russell E. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, Hamilton, ON L8N 3Z5, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2014年 / 196卷 / 18期

基金：

加拿大健康研究院;

关键词：

CDP-DIGLYCERIDE SYNTHETASE; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; LIPOPOLYSACCHARIDE INSERTION; PHOSPHATIDIC-ACID; STRUCTURAL BASIS; MOLECULAR-BASIS; BIOGENESIS; IDENTIFICATION; ACCUMULATION;

D O I：

10.1128/JB.02043-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lately, researchers have been actively investigating Escherichia coli lptD mutants, which exhibit reduced transport of lipopolysaccharide to the cell surface. In this issue of the Journal of Bacteriology, Sutterlin et al. (H. A. Sutterlin, S. Zhang, and T. J. Silhavy, J. Bacteriol. 196:3214-3220, 2014) now reveal an important functional role for phosphatidic acid in fortifying the outer membrane permeability barrier in certain lptD mutant backgrounds. These findings come on the heels of the first reports of two LptD crystal structures, which now provide a structural framework for interpreting lptD genetics.

引用

页码：3209 / 3213

页数：5

共 31 条

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