Role of viability imaging in the post- STICH era

被引:4
作者
Shah, Benoy Nalin [1 ,2 ,3 ]
Senior, Roxy [1 ,2 ,3 ]
机构
[1] Royal Brompton Hosp, Dept Cardiol, London SW3 6NP, England
[2] Royal Brompton Hosp, Cardiovasc Biomed Res Unit, London SW3 6LY, England
[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
关键词
hibernating myocardium; imaging; ischemia; viability; LEFT-VENTRICULAR DYSFUNCTION; MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY; CORONARY-ARTERY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; ENHANCED MAGNETIC-RESONANCE; LONG-TERM SURVIVAL; ISCHEMIC CARDIOMYOPATHY; HIBERNATING MYOCARDIUM; VIABLE MYOCARDIUM; STRESS ECHOCARDIOGRAPHY;
D O I
10.1097/HCO.0000000000000047
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewRecent results from prospective randomized controlled trials examining the management of patients with ischemic cardiomyopathy (ICM) have questioned both the added value of revascularization over contemporary optimal medical therapy (OMT) and the use of viability testing as a gate-keeper to revascularization. The purpose of this review is to summarize recent trial evidence before discussing future perspectives in the field.Recent findingsThe Surgical Treatment of Ischemic Heart Failure (STICH) trial, PPAR-2 trial and Heart Failure Revascularisation Trial have all reported their results within the past 5 years. None of these trials found revascularization superior to OMT in improving survival of ICM patients. Additionally, the STICH trial's viability substudy suggested that pretreatment viability testing was not beneficial.SummaryICM patients remain a clinical conundrum. The numerous limitations of the recent RCTs have led to uncertainty about optimal management. Revascularization continues to be offered to patients with evidence of myocardial viability. Further studies are required to answer the outstanding questions in the management of patients with ICM.
引用
收藏
页码:145 / 151
页数:7
相关论文
共 26 条
  • [1] Qualitative and Quantitative Real Time Myocardial Contrast Echocardiography for Detecting Hibernating Myocardium
    Aleixo Fernandes, Daniela Ribeiro
    Tsutsui, Jeane Mike
    Bocchi, Edimar Alcides
    Machado Cesar, Luiz Antonio
    Nunes Sbano, Joao Cesar
    Franchini Ramires, Jose Antonio
    Mathias, Wilson, Jr.
    [J]. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2011, 28 (03): : 342 - 349
  • [2] F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management 2002 of patients with severe left ventricular dysfunction and suspected coronary disease: A randomized, controlled trial (PARR-2)
    Beanlands, Rob S. B.
    Nichol, Graham
    Huszti, Ella
    Humen, Dennis
    Racine, Normand
    Freeman, Michael
    Gulenchyn, Karen Y.
    Garrard, Linda
    deKemp, Robert
    Guo, Ann
    Ruddy, Terrence D.
    Benard, Francois
    Lamy, Andre
    Iwanochko, Robert M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (20) : 2002 - 2012
  • [3] Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction
    Bonow, Robert O.
    Maurer, Gerald
    Lee, Kerry L.
    Holly, Thomas A.
    Binkley, Philip F.
    Desvigne-Nickens, Patrice
    Drozdz, Jaroslaw
    Farsky, Pedro S.
    Feldman, Arthur M.
    Doenst, Torsten
    Michler, Robert E.
    Berman, Daniel S.
    Nicolau, Jose C.
    Pellikka, Patricia A.
    Wrobel, Krzysztof
    Alotti, Nasri
    Asch, Federico M.
    Favaloro, Liliana E.
    She, Lilin
    Velazquez, Eric J.
    Jones, Robert H.
    Panza, Julio A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (17) : 1617 - 1625
  • [4] The Heart Failure Revascularisation Trial (HEART)
    Cleland, John G. F.
    Calvert, Melanie
    Freemantle, Nick
    Arrow, Yvonne
    Ball, Stephen G.
    Bonser, Robert S.
    Chattopadhyay, Sudipta
    Norell, Michael S.
    Pennell, Dudley J.
    Senior, Roxy
    [J]. EUROPEAN JOURNAL OF HEART FAILURE, 2011, 13 (02) : 227 - 233
  • [5] Parametric imaging of myocardial viability using 15O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR
    de Haan, Stefan
    Harms, Hendrik J.
    Lubberink, Mark
    Allaart, Cornelis P.
    Danad, Ibrahim
    Chen, Weena J. Y.
    Diamant, Michaela
    van Rossum, Albert C.
    Iida, Hidehiro
    Lammertsma, Adriaan A.
    Knaapen, Paul
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (08) : 1240 - 1245
  • [6] Scar imaging using multislice computed tomography versus metabolic imaging by F-18 FDG positron emission tomography: A pilot study
    Dwivedi, Girish
    Al-Shehri, Halia
    deKemp, Robert A.
    Ali, Iftikhar
    Alghamdi, Abdul Aziz
    Klein, Ran
    Scullion, Andrew
    Ruddy, Terrence D.
    Beanlands, Rob S.
    Chow, Benjamin J. W.
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (02) : 739 - 745
  • [7] Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET
    Fuchs, Tobias A.
    Ghadri, Jelena R.
    Stehli, Julia
    Gebhard, Catherine
    Kazakauskaite, Egle
    Klaeser, Bernd
    Gaemperli, Oliver
    Fiechter, Michael
    Kaufmann, Philipp A.
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (12) : 1920 - 1926
  • [8] Prognostic Value of Myocardial Viability by Delayed-Enhanced Magnetic Resonance in Patients With Coronary Artery Disease and Low Ejection Fraction Impact of Revascularization Therapy
    Gerber, Bernhard L.
    Rousseau, Michel F.
    Ahn, Sylvie A.
    de Waroux, Jean-Benoit le Polain
    Pouleur, Anne-Catherine
    Phlips, Thomas
    Vancraeynest, David
    Pasquet, Agnes
    Vanoverschelde, Jean-Louis J.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (09) : 825 - 835
  • [9] The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.
    Kim, RJ
    Wu, E
    Rafael, A
    Chen, EL
    Parker, MA
    Simonetti, O
    Klocke, FJ
    Bonow, RO
    Judd, RM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (20) : 1445 - 1453
  • [10] Standardized cardiovascular magnetic resonance imaging (CMR) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols
    Kramer, Christopher M.
    Barkhausen, Jorg
    Flamm, Scott D.
    Kim, Raymond J.
    Nagel, Eike
    [J]. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2008, 10 (1)