Pro-resolving lipid mediators are leads for resolution physiology

被引：2200
作者：
Serhan, Charles N. [1 ,2 ]
机构：
[1] Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat & Pain Med, Harvard Inst Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
NATURE | 2014年 / 510卷 / 7503期
基金：
美国国家卫生研究院;
关键词：
TRIGGERED 15-EPI-LIPOXIN A(4); ACUTE INFLAMMATORY RESPONSES; DOCOSAHEXAENOIC ACID; LIPOXIN A(4); NEUROPROTECTIN D1; PROTECTIN D1; ANTIINFLAMMATORY PROPERTIES; STEREOCHEMICAL ASSIGNMENT; PRORESOLVING MEDIATORS; LEUKOCYTE RECRUITMENT;
D O I：
10.1038/nature13479
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.
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收藏
页码：92 / 101
页数：10
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