Chemotherapy-related cognitive dysfunction: current animal studies and future directions

被引：102

作者：

Seigers, R. ^{[1
]}

Schagen, S. B. ^{[1
]}

Van Tellingen, O. ^{[2
]}

Dietrich, J. ^{[3
]}

机构：

[1] Netherlands Canc Inst, Dept Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Mol Biol, Amsterdam, Netherlands

[3] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp,Canc Ctr,Div Neurooncol, Boston, MA 02115 USA

来源：

BRAIN IMAGING AND BEHAVIOR | 2013年 / 7卷 / 04期

关键词：

Review; Animal; Chemotherapy; Cognition; Impairment; Cytostatic; HIPPOCAMPAL CELL-PROLIFERATION; INDUCED OXIDATIVE STRESS; CENTRAL-NERVOUS-SYSTEM; BREAST-CANCER; MEMORY DEFICITS; IN-VIVO; INTRATHECAL METHOTREXATE; PROPHYLACTIC ACTION; ADULT NEUROGENESIS; DRUG ADRIAMYCIN;

D O I：

10.1007/s11682-013-9250-3

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors. There is a growing number of preclinical studies addressing this issue, thereby extending our knowledge of the mechanisms underlying chemotherapy-induced neurotoxicity. In this review, we will summarize the recent advances and important findings presented in these studies. Emerging challenges, such as the development of neuroprotective strategies, and the role of the blood-brain barrier on cognitive impairment will be described and future directions in this field of investigation will be outlined.

引用

页码：453 / 459

页数：7

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