Metastasis Organotropism: Redefining the Congenial Soil

被引：258

作者：

Gao, Yang ^{[1
,2
,3
]}

Bado, Igor ^{[1
,2
,3
]}

Wang, Hai ^{[1
,2
,3
]}

Zhang, Weijie ^{[1
,2
,3
]}

Rosen, Jeffrey M. ^{[2
,3
]}

Zhang, Xiang H-F ^{[1
,2
,3
,4
]}

机构：

[1] Baylor Coll Med, Lester & Sue Smith Breast Ctr, One Baylor Plaza, Houston, TX 77030 USA

[2] Baylor Coll Med, Dan L Duncan Canc Ctr, One Baylor Plaza, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, One Baylor Plaza, Houston, TX 77030 USA

[4] Baylor Coll Med, McNair Med Inst, One Baylor Plaza, Houston, TX 77030 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期

关键词：

BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; REPROGRAMS GLUCOSE-METABOLISM; BONE METASTASIS; BRAIN-METASTASIS; OVARIAN-CANCER; PROSTATE-CANCER; PREMETASTATIC NICHE; LUNG METASTASIS; LIVER METASTASIS;

D O I：

10.1016/j.devcel.2019.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as 'organotropism.'' Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.

引用

页码：375 / 391

页数：17

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