Metastasis Organotropism: Redefining the Congenial Soil

被引：258

作者：

Gao, Yang ^{[1
,2
,3
]}

Bado, Igor ^{[1
,2
,3
]}

Wang, Hai ^{[1
,2
,3
]}

Zhang, Weijie ^{[1
,2
,3
]}

Rosen, Jeffrey M. ^{[2
,3
]}

Zhang, Xiang H-F ^{[1
,2
,3
,4
]}

机构：

[1] Baylor Coll Med, Lester & Sue Smith Breast Ctr, One Baylor Plaza, Houston, TX 77030 USA

[2] Baylor Coll Med, Dan L Duncan Canc Ctr, One Baylor Plaza, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, One Baylor Plaza, Houston, TX 77030 USA

[4] Baylor Coll Med, McNair Med Inst, One Baylor Plaza, Houston, TX 77030 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期

关键词：

BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; REPROGRAMS GLUCOSE-METABOLISM; BONE METASTASIS; BRAIN-METASTASIS; OVARIAN-CANCER; PROSTATE-CANCER; PREMETASTATIC NICHE; LUNG METASTASIS; LIVER METASTASIS;

D O I：

10.1016/j.devcel.2019.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as 'organotropism.'' Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.

引用

页码：375 / 391

页数：17

共 180 条

[1] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2] EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration [J].

Aiello, Nicole M. ;

Maddipati, Ravikanth ;

Norgard, Robert J. ;

Balli, David ;

Li, Jinyang ;

Yuan, Salina ;

Yamazoe, Taiji ;

Black, Taylor ;

Sahmoud, Amine ;

Furth, Emma E. ;

Bar-Sagi, Dafna ;

Stanger, Ben Z. .

DEVELOPMENTAL CELL, 2018, 45 (06) :681-+

[3] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[4] The lung microenvironment: an important regulator of tumour growth and metastasis [J].

Altorki, Nasser K. ;

Markowitz, Geoffrey J. ;

Gao, Dingcheng ;

Port, Jeffrey L. ;

Saxena, Ashish ;

Stiles, Brendon ;

McGraw, Timothy ;

Mittal, Vivek .

NATURE REVIEWS CANCER, 2019, 19 (01) :9-31

[5] Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer [J].

Bendinelli, Paola ;

Maroni, Paola ;

Matteucci, Emanuela ;

Luzzati, Alessandro ;

Perrucchini, Giuseppe ;

Desiderio, Maria Alfonsina .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2014, 1843 (04) :815-826

[6] Sites of Metastases of Anaplastic Thyroid Carcinoma: Autopsy Findings in 45 Cases from a Single Institution [J].

Besic, Nikola ;

Gazic, Barbara .

THYROID, 2013, 23 (06) :709-713

[7] Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape [J].

Bidwell, Bradley N. ;

Slaney, Clare Y. ;

Withana, Nimali P. ;

Forster, Sam ;

Cao, Yuan ;

Loi, Sherene ;

Andrews, Daniel ;

Mikeska, Thomas ;

Mangan, Niamh E. ;

Samarajiwa, Shamith A. ;

de Weerd, Nicole A. ;

Gould, Jodee ;

Argani, Pedram ;

Moeller, Andreas ;

Smyth, Mark J. ;

Anderson, Robin L. ;

Hertzog, Paul J. ;

Parker, Belinda S. .

NATURE MEDICINE, 2012, 18 (08) :1224-1231

[8] Genes that mediate breast cancer metastasis to the brain [J].

Bos, Paula D. ;

Zhang, Xiang H. -F. ;

Nadal, Cristina ;

Shu, Weiping ;

Gomis, Roger R. ;

Nguyen, Don X. ;

Minn, Andy J. ;

van de Vijver, Marc J. ;

Gerald, William L. ;

Foekens, John A. ;

Massague, Joan .

NATURE, 2009, 459 (7249) :1005-U137

[9] Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis [J].

Bu, Pengcheng ;

Chen, Kai-Yuan ;

Xiang, Kun ;

Johnson, Christelle ;

Crown, Scott B. ;

Rakhilin, Nikolai ;

Ai, Yiwei ;

Wang, Lihua ;

Xi, Rui ;

Astapova, Inna ;

Han, Yan ;

Li, Jiahe ;

Barth, Bradley B. ;

Lu, Min ;

Gao, Ziyang ;

Mines, Robert ;

Zhang, Liwen ;

Herman, Mark ;

Hsu, David ;

Zhang, Guo-Fang ;

Shen, Xiling .

CELL METABOLISM, 2018, 27 (06) :1249-+

[10] Metastatic patterns of prostate cancer:: An autopsy study of 1,589 patients [J].

Bubendorf, L ;

Schöpfer, A ;

Wagner, U ;

Sauter, G ;

Moch, H ;

Willi, N ;

Gasser, TC ;

Mihatsch, MJ .

HUMAN PATHOLOGY, 2000, 31 (05) :578-583

← 1 2 3 4 5 6 7 8 9 10 →