Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer

被引：18

作者：

Patil, Sumersing ^{[1
,2
]}

Patil, Sohan ^{[1
]}

Gawali, Suhas ^{[1
]}

Shende, Shrikant ^{[1
]}

Jadhav, Shraddha ^{[1
]}

Basu, Sudipta ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Pune, Dept Chem, Pune 411021, Maharashtra, India

[2] Univ Pune, Inst Bioinformat & Biotechnol, Pune 411007, Maharashtra, India

来源：

RSC ADVANCES | 2013年 / 3卷 / 43期

关键词：

DOXORUBICIN-INDUCED CARDIOMYOPATHY; BILE-ACIDS; PHASE-I; NANOTECHNOLOGY; PACLITAXEL; PATHWAY; CELLS; CHEMOTHERAPY; CHEMISTRY; EFFICACY;

D O I：

10.1039/c3ra42994f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells.

引用

页码：19760 / 19764

页数：5

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