iDQC Anisotropy Map Imaging for Tumor Tissue Characterization In Vivo

被引：19

作者：

Branca, Rosa T. ^{[1
]}

Chen, Yuming M. ^{[1
]}

Mouraviev, Vladimir ^{[2
]}

Galiana, Gigi ^{[1
,3
]}

Jenista, Elizabeth R. ^{[1
]}

Kumar, Challa ^{[4
]}

Leuschner, Carola ^{[5
]}

Warren, Warren S. ^{[1
]}

机构：

[1] Duke Univ, Ctr Mol & Biomol Imaging, Durham, NC 27710 USA

[2] Duke Univ, Dept Urol, Durham, NC USA

[3] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[4] Ctr Adv Microstruct & Devices, Baton Rouge, LA USA

[5] Pennington Biomed Res Ctr, Baton Rouge, LA USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2009年 / 61卷 / 04期

基金：

美国国家卫生研究院;

关键词：

iMQC; iDQC; dipolar field; CRAZED; SPION; LHRH; SIMULTANEOUS ACQUISITION; CONTRAST ENHANCEMENT; MULTIPLE ORDERS; QUANTUM; NANOPARTICLES; FIELDS; IRON; NMR;

D O I：

10.1002/mrm.21925

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue. Magn Reson Med 61:937-943, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：937 / 943

页数：7

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