One-pot synthetic procedure for 2,2′-disubstituted biaryls via the Suzuki coupling reaction of aryl triflates in a biphasic solvent system

被引：13
|
作者：
Miura, Masanori [1 ]
Koike, Takanori [1 ]
Ishihara, Tsukasa [1 ]
Hirayama, Fukushi [1 ]
Sakamoto, Shuichi [1 ]
Okada, Minoru [1 ]
Ohta, Mitsuaki [1 ]
Tsukamoto, Shin-ichi [1 ]
机构：
[1] Astellas Pharma Inc, Inst Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 24期
关键词：
biphasic solvent; 2,2 '-disubstituted biaryls; one-pot reaction; Suzuki coupling reaction; tetra(alkoxo)diboron;
D O I：
10.1080/00397910600948088
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthetic procedure for 2,2'-disubstituted biaryls was developed via a Suzuki cross-coupling reaction of aryl triflates in a biphasic solvent system. The effects of various bases and solvents were investigated. Results showed that the Na2CO3 - toluene/H2O combination gave the highest yields.
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收藏
页码：3809 / 3820
页数：12
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