Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration

被引:148
作者
De Nicola, Alejandro F. [1 ,2 ]
Labombarda, Florencia [1 ,2 ]
Gonzalez Deniselle, Maria Claudia [1 ,2 ]
Gonzalez, Susana L. [1 ,2 ]
Garay, Laura [1 ,2 ]
Meyer, Maria [1 ]
Gargiulo, Gisella [1 ]
Guennoun, Rachida [3 ,4 ]
Schumacher, Michael [3 ,4 ]
机构
[1] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt, Lab Neuroendocrine Biochem, RA-1428 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Dept Human Biochem, Buenos Aires, DF, Argentina
[3] Univ Paris 11, Le Kremlin Bicetre, France
[4] INSERM, UMR788, Le Kremlin Bicetre, France
关键词
Brain injury; Myelination; Oligodendrocytes; Neuroactive steroid; Neurodegeneration; Progesterone; Spinal cord; Wobbler mouse; SPINAL-CORD-INJURY; MICROTUBULE-ASSOCIATED PROTEIN-2; MOTOR-NEURON DISEASE; MESSENGER-RNA EXPRESSION; MYELIN BASIC-PROTEIN; NEUROTROPHIC FACTOR EXPRESSION; AMYOTROPHIC-LATERAL-SCLEROSIS; CENTRAL-NERVOUS-SYSTEM; FACTOR GENE-EXPRESSION; BRAIN-INJURY;
D O I
10.1016/j.yfrne.2009.03.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote remyelination, axonal regeneration and the recovery of function. In traumatic brain injury (TBI), progesterone has the ability to reduce edema and inflammatory cytokines, prevent neuronal loss and improve functional outcomes. Clinical trials have shown that short-and long-term progesterone treatment induces a significant improvement in the level of disability among patients with brain injury. In experimental spinal cord injury (SCI), molecular markers of functional motoneurons become impaired, including brain-derived neurotrophic factor (BDNF) mRNA, Na,K-ATPase mRNA, microtubule-associated protein 2 and choline acetyltransferase (ChAT). SO also produces motoneuron chromatolysis. Progesterone treatment restores the expression of these molecules while chromatolysis subsided. SCI also causes oligodendrocyte loss and demyelination. In this case, a short progesterone treatment enhances proliferation and differentiation of oligodendrocyte progenitors into mature myelin-producing cells, whereas prolonged treatment increases a transcription factor (Olig1) needed to repair injury-induced demyelination. Progesterone neuroprotection has also been shown in motoneuron neurodegeneration. In Wobbler mice spinal cord, progesterone reverses the impaired expression of BDNF, ChAT and Na,K-ATPase, prevents vacuolar motoneuron degeneration and the development of mitochondrial abnormalities, while functionally increases muscle strength and the survival of Wobbler mice. Multiple mechanisms contribute to these progesterone effects, and the role played by classical nuclear receptors. extra nuclear receptors, membrane receptors, and the reduced metabolites of progesterone in neuroprotection and myelin formation remain an exciting field worth of exploration. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:173 / 187
页数:15
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