Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12

被引：25

作者：

Chen, Yan ^{[1
,2
]}

Zou, Ge ^{[2
]}

Yang, Wencong ^{[2
]}

Zhao, Yingying ^{[1
]}

Tan, Qi ^{[2
]}

Chen, Lin ^{[3
]}

Wang, Jinmei ^{[1
]}

Ma, Changyang ^{[1
]}

Kang, Wenyi ^{[1
]}

She, Zhigang ^{[2
]}

机构：

[1] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China

[3] Huanghe Sci & Technol Coll, Zhengzhou Key Lab Synthet Biol Nat Prod, Henan Joint Int Res Lab Drug Discovery Small Mol, Zhengzhou 450063, Peoples R China

来源：

MARINE DRUGS | 2021年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

mangrove endophytic fungus; Diaporthe sp; anti-inflammatory activity;

D O I：

10.3390/md19020056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B-C (2,3) and three new alpha-pyrone derivatives, diaporpyrones A-C (4-6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC50 values of 21.5 and 12.5 mu M, respectively.

引用

页数：10

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