Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

被引：22

作者：

Guo, Yishun ^{[1
,2
]}

Qian, Siyuan ^{[1
]}

Wang, Lu ^{[1
]}

Zeng, Jiahong ^{[1
]}

Miao, Renjie ^{[1
]}

Meng, Yongchun ^{[3
]}

Jin, Yingying ^{[1
]}

Chen, Hao ^{[1
]}

Wang, Bailiang ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Hosp Eye, Res Grp Adv Ophthalm Bion Interface Mat & Drug De, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, State Key Lab Ophthalmol Optometry & Visual Sci, Wenzhou 325027, Peoples R China

[3] Binzhou Med Univ, Yantai Affiliated Hosp, Cent Lab, 717 Jinbu St, Yantai 264100, Shandong, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2020年 / 8卷 / 44期

基金：

中国国家自然科学基金;

关键词：

DEGRADABLE MULTILAYER FILMS; PHOTOTHERMAL ABLATION; DRUG-RELEASE; ANTIBACTERIAL; NANOPARTICLES; CONSTRUCTION; TRANSPARENT; FORMULATION; INHIBITION; SURFACES;

D O I：

10.1039/d0tb01508c

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brush-modified contact lenses through dynamic chemical bonds between polyphenolic hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated great promise in the prevention of bacterial keratitis, which could be attributed to the enhanced retention time and drug bioavailability.

引用

页码：10087 / 10092

页数：6

共 27 条

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