Neurotransmitter-related genes and antipsychotic response: pharmacogenetics meets psychiatric treatment

被引：17
作者：
Arranz, MJ [1 ]
Kerwin, RW [1 ]
机构：
[1] Inst Psychiat, Dept Psychol Med, Sect Clin Neuropharmacol, London SE5 8AF, England
来源：
ANNALS OF MEDICINE | 2000年 / 32卷 / 02期
关键词：
antipsychotic response; neuroreceptors; pharmacogenetics;
D O I：
10.3109/07853890009011762
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pharmacogenetic research into neurotransmitter-related genes is helping to unravel genetic factors that determine antipsychotic response, Several genetic mutations in neurotransmitter receptors targeted by antipsychotic drugs have been found to be related to clinical response, Modern molecular genetic techniques will facilitate the identification of those mutations that determine treatment response. Future psychiatric prescription will include the genetic characterization of neurotransmitter receptors for the selection of the most beneficial drug according to the individual's pharmacogenetic profile.
引用
收藏
页码：128 / 133
页数：6
相关论文
共 51 条
[1]   ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE [J].
ARRANZ, M ;
COLLIER, D ;
SODHI, M ;
BALL, D ;
ROBERTS, G ;
PRICE, J ;
SHAM, P ;
KERWIN, R .
LANCET, 1995, 346 (8970) :281-282
[2]   Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine [J].
Arranz, MJ ;
Collier, DA ;
Munro, J ;
Sham, P ;
Kirov, G ;
Sodhi, M ;
Roberts, G ;
Price, J ;
Kerwin, RW .
NEUROSCIENCE LETTERS, 1996, 217 (2-3) :177-178
[3]   Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response [J].
Arranz, MJ ;
Li, T ;
Munro, J ;
Liu, X ;
Murray, R ;
Collier, DA ;
Kerwin, RW .
PHARMACOGENETICS, 1998, 8 (06) :481-484
[4]   Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response [J].
Arranz, MJ ;
Munro, J ;
Sham, P ;
Kirov, G ;
Murray, RM ;
Collier, DA ;
Kerwin, RS .
SCHIZOPHRENIA RESEARCH, 1998, 32 (02) :93-99
[5]  
ARRANZ MJ, IN PRESS LANCET
[6]   Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia [J].
Basile, VS ;
Masellis, M ;
Badri, F ;
Paterson, AD ;
Meltzer, HY ;
Lieberman, JA ;
Potkin, SG ;
Macciardi, F ;
Kennedy, JL .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (01) :17-27
[7]  
Cichon S, 1996, AM J MED GENET, V67, P424, DOI 10.1002/(SICI)1096-8628(19960726)67:4<424::AID-AJMG21>3.0.CO
[8]  
2-K
[9]   Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs [J].
Cohen, BM ;
Ennulat, DJ ;
Centorrino, F ;
Matthysse, S ;
Konieczna, H ;
Chu, HM ;
Cherkerzian, S .
PSYCHOPHARMACOLOGY, 1999, 141 (01) :6-10
[10]   Analysis of neuroleptic binding affinities and potencies for the different human D2 dopamine receptor missense variants [J].
Cravchik, A ;
Sibley, DR ;
Gejman, PV .
PHARMACOGENETICS, 1999, 9 (01) :17-23
123456