Reduce, reuse, and recycle

被引：5
作者：
Robinson, CR [1 ]
机构：
[1] Univ Delaware, Dept Chem & Biochem, Delaware Biotechnol Inst, Newark, DE 19711 USA
来源：
NATURE BIOTECHNOLOGY | 2002年 / 20卷 / 09期
关键词：
D O I：
10.1038/nbt0902-879
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Reducing a cytokine's affinity for its receptor increases its ability to be reused and recycled, and could enhance its therapeutic potency.
引用
收藏
页码：879 / 880
页数：2
相关论文
共 11 条
  • [1] Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme
    Aritomi, M
    Kunishima, N
    Okamoto, T
    Kuroki, R
    Ota, Y
    Morikawa, K
    [J]. NATURE, 1999, 401 (6754) : 713 - 718
  • [2] EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH FACTOR-ALPHA - DIFFERENTIAL INTRACELLULAR ROUTING AND PROCESSING OF LIGAND-RECEPTOR COMPLEXES
    EBNER, R
    DERYNCK, R
    [J]. CELL REGULATION, 1991, 2 (08): : 599 - 612
  • [3] INTRACELLULAR TRAFFICKING OF EPIDERMAL GROWTH-FACTOR FAMILY LIGANDS IS DIRECTLY INFLUENCED BY THE PH SENSITIVITY OF THE RECEPTOR-LIGAND INTERACTION
    FRENCH, AR
    TADAKI, DK
    NIYOGI, SK
    LAUFFENBURGER, DA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) : 4334 - 4340
  • [4] Controlling receptor/ligand trafficking: Effects of cellular and molecular properties on endosomal sorting
    French, AR
    Lauffenburger, DA
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 1997, 25 (04) : 690 - 707
  • [5] HUBEL K, J INFECT DIS, V185, P1490
  • [6] Aggregation of granulocyte colony stimulating factor under physiological conditions: Characterization and thermodynamic inhibition
    Krishnan, S
    Chi, EY
    Webb, JN
    Chang, BS
    Shan, DX
    Goldenberg, M
    Manning, MC
    Randolph, TW
    Carpenter, JF
    [J]. BIOCHEMISTRY, 2002, 41 (20) : 6422 - 6431
  • [7] Linderman J, 1993, RECEPTORS MODELS BIN
  • [8] Granulocyte colony stimulating factors: How different are they? How to make a decision?
    Martin-Christin, F
    [J]. ANTI-CANCER DRUGS, 2001, 12 (03) : 185 - 191
  • [9] Reddy CC, 1996, J CELL PHYSIOL, V166, P512, DOI 10.1002/(SICI)1097-4652(199603)166:3<512::AID-JCP6>3.0.CO
  • [10] 2-S
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