Cortical thickness increases with levomilnacipran treatment in a pilot randomised double-blind placebo-controlled trial in late-life depression
被引:10
作者:
Krause-Sorio, Beatrix
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Krause-Sorio, Beatrix
[1
]
Kilpatrick, Lisa
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机构:
Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Kilpatrick, Lisa
[1
]
Siddarth, Prabha
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Siddarth, Prabha
[1
]
Ercoli, Linda
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Ercoli, Linda
[1
]
Laird, Kelsey T.
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Laird, Kelsey T.
[1
]
Aguilar-Faustino, Yesenia
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Aguilar-Faustino, Yesenia
[1
]
Milillo, Michaela M.
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Milillo, Michaela M.
[1
]
Narr, Katherine L.
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Narr, Katherine L.
[1
,2
]
Lavretsky, Helen
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Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
Lavretsky, Helen
[1
]
机构:
[1] Univ Calif Los Angeles, Dept Psychiat, Semel Inst Neurosci, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA
antidepressant;
cortical thickness;
late-life depression;
magnetic resonance imaging;
neuroimaging;
EXTENDED-RELEASE;
MAJOR DEPRESSION;
ALZHEIMERS-DISEASE;
CEREBRAL-CORTEX;
RATING-SCALE;
DISORDER;
EFFICACY;
VOLUME;
PLASTICITY;
PATTERNS;
D O I:
10.1111/psyg.12475
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
Background Late-life depression (LLD) is associated with significant medical comorbidity, cognitive impairment, and suboptimal treatment response compared to depression experienced earlier in life. Levomilnacipran (LVM) is a novel antidepressant the effects of which on neuroplasticity have not yet been investigated. We investigated the effect of LVM on cortical thickness in a pilot randomised placebo-controlled trial in LLD. Methods Twenty-nine adults (>= 60 years) with major depression (48.3% female; mean age = 71.5 +/- 5.8 years; mean education = 16.0 +/- 1.7 years) were randomised to either LVM or placebo for 12 weeks. T1-weighted images were acquired at baseline and 12 weeks. Thirteen subjects (six LVM and seven placebo) completed the study. Group differences in cortical thickness change across the study period were evaluated, with age and total intracranial volume included as covariates. Results Dropout rates did not differ significantly between groups. The LVM group had significantly more side effects, but no serious adverse events were reported. Lower LVM dose (<= 40 mg) was better tolerated than higher doses (80-120 mg). Additionally, the LVM group showed a larger increase in cortical thickness in the right postcentral gyrus (primary somatosensory), supramarginal gyrus (sensory association region), and lateral occipital cortex (visual cortex) compared to the placebo group and greater reductions in the left insula. Conclusions LVM may be less tolerable by older adults with depression and the effects on cortical thickness across sensory and sensory association regions may be related to the experience of side effects. Larger studies are necessary to evaluate treatment efficacy, tolerability, and neural effects of LVM in LLD.
机构:
Childrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Pediat, 4650 Sunset Blvd,MS 135, Los Angeles, CA 90027 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Bansal, R.
Hellerstein, D. J.
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机构:
New York State Psychiat Inst & Hosp, Div Clin Therapeut, Depress Evaluat Serv, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Hellerstein, D. J.
Peterson, B. S.
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h-index: 0
机构:
Childrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Psychiat, Los Angeles, CA 90033 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
机构:
Univ Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, FinlandUniv Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, Finland
Castren, E.
Antila, H.
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机构:
Univ Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, FinlandUniv Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, Finland
机构:
Childrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Pediat, 4650 Sunset Blvd,MS 135, Los Angeles, CA 90027 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Bansal, R.
Hellerstein, D. J.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Psychiat Inst & Hosp, Div Clin Therapeut, Depress Evaluat Serv, New York, NY 10032 USA
Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Hellerstein, D. J.
Peterson, B. S.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Psychiat, Los Angeles, CA 90033 USAChildrens Hosp Los Angeles, Inst Developing Mind, Los Angeles, CA 90027 USA
机构:
Univ Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, FinlandUniv Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, Finland
Castren, E.
Antila, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, FinlandUniv Helsinki, Neurosci Ctr, Helsinki Inst Life Sci HiLife, POB 56 Viikinkaari 4, FIN-00014 Helsinki, Finland