Can the Positive and Negative Syndrome scale (PANSS) differentiate treatment-resistant from non-treatment-resistant schizophrenia? A factor analytic investigation based on data from the Pattern cohort study

被引：16

作者：

Freitas, Rosana ^{[1
]}

dos Santos, Bernardo ^{[1
]}

Altamura, Carlo ^{[2
]}

Bernasconi, Corrado ^{[3
]}

Corral, Ricardo ^{[4
]}

Evans, Jonathan ^{[5
]}

Malla, Ashok ^{[6
]}

Krebs, Marie-Odile ^{[7
]}

Nordstroem, Anna-Lena ^{[3
]}

Zink, Mathias ^{[8
]}

Haro, Josep Maria ^{[9
,10
]}

Elkis, Helio ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Sao Paulo, SP, Brazil

[2] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy

[3] F Hoffmann La Roche Ltd, Basel, Switzerland

[4] FETEM, Cervino 4634 5th Floor Apt B,C1425AHQ, Buenos Aires, DF, Argentina

[5] Univ Bristol, Ctr Acad Mental Hlth, Bristol BS8 2BN, Avon, England

[6] McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ H4H 1R3, Canada

[7] Univ Paris 05, Hop St Anne, INSERM, Serv Hosp Univ,Lab Physiopathol Malad Psychiat, Paris, France

[8] Heidelberg Univ, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

[9] CIBERSAM, Parc Sanitari St Joan Deu, Barcelona, Spain

[10] Univ Barcelona, Barcelona, Spain

来源：

PSYCHIATRY RESEARCH | 2019年 / 276卷

关键词：

5-FACTOR MODEL; PERSISTENT SYMPTOMS; TREATMENT RESPONSE; DSM-IV; CLOZAPINE; VALIDATION; ANTIPSYCHOTICS; RISPERIDONE; DEFINITION; VERSION;

D O I：

10.1016/j.psychres.2019.05.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Treatment-Resistant Schizophrenia (TRS) and Non-Treatment-Resistant Schizophrenia (NTRS) may represent different subtypes of schizophrenia. However, few studies have investigated their PANSS symptom dimensions by Exploratory (EFA) or Confirmatory (CFA). Data from the present study are derived from 1429 patients of the Pattern study. TRS was defined by the use of clozapine in the previous year whereas NTRS by the use of non-clozapine antipsychotics ("by proxy"). Factors were chosen based on the Kaiser criterion and considered valid when loadings were greater than or equal to 0.5. The fit to the data was evaluated by CFA in comparison with well-established PANSS models, using fit indexes. The EFA yielded similar five-factor model in both groups: Negative, Positive, Anxiety/Depression, Cognitive and Excited. CFA showed a satisfactory, but not perfect, fit to the data, as compared with the previous PANSS factor analytic models. Despite the limitations regarding the 'by proxy' definition of TRS, the results of the present study show that there are no differences in the factorial structure of PANSS in patients with TRS and NTRS.

引用

页码：210 / 217

页数：8

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