SYNTHESIS, MOLECULAR DOCKING, MOLECULAR PROPERTIES ESTIMATIONS AND ANTIINFLAMATORY ACTIVITY OF 5, 7-DIHYDROXY-3' PRENYL FLAVANONE

被引：0

作者：

Krishna, Badikela Rama ^{[1
]}

Ch, Rathnakar ^{[1
]}

Kemisetti, Durgaprasad ^{[2
]}

Surendran, Vijayaraj ^{[3
]}

Ravula, Parameshwar ^{[3
]}

机构：

[1] Guru Nanak Inst Tech Campus, Dept Pharmaceut Anal & Qual Assurance, Sch Pharm, Hyderabad, Telangana, India

[2] Assam Down Town Univ, Fac Pharmaceut Sci, Gauhati, Assam, India

[3] Amity Univ, Amity Inst Pharm, Dept Pharmaceut Chem, Gwalior, Madhya Pradesh, India

来源：

HETEROCYCLIC LETTERS | 2022年 / 12卷 / 04期

关键词：

Flavanone; Anti-inflammatory activity; Molecular docking; Synthesis; FLAVONOIDS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel compound 5, 7-dihydroxy-3'- prenyl flavanone was synthesized by introducing prenyl moiety at 3(rd) position of flavanone nucleus. The structures of synthesized compounds were confirmed by H-1 NMR and mass spectral data. The anti-inflammatory screening of the synthesized compound was performed by in vivo using carragenan induced paw oedema method. In silico prediction of molecular and drug-likeness properties of target compound was found to be promising. The results are obtained from anti-inflammatory activity and molecular docking suggested that test compound could be considered as drug candidate for antiinflammatory activity.

引用

页码：797 / 804

页数：8

共 19 条

[1] Microwave-Assisted Synthesis of Some Quinoxaline-Incorporated Schiff Bases and Their Biological Evaluation [J].