Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

被引：515

作者：

Yan, Jing ^{[1
,2
]}

Bassler, Bonnie L. ^{[2
,3
]}

机构：

[1] Princeton Univ, Dept Mech & Aerosp Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

CELL HOST & MICROBE | 2019年 / 26卷 / 01期

基金：

美国国家科学基金会;

关键词：

PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-EPIDERMIDIS; METABOLIC-ACTIVITY; CELLS; RESISTANCE; GENE;

D O I：

10.1016/j.chom.2019.06.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.

引用

页码：15 / 21

页数：7

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