Efficient synthesis of neurotrophic honokiol using Suzuki-Miyaura reactions

被引：11

作者：

Harada, Kenichi ^{[1
]}

Arioka, Chiharu ^{[1
]}

Miyakita, Akina ^{[1
]}

Kubo, Miwa ^{[1
]}

Fukuyama, Yoshiyasu ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 43期

关键词：

Honokiol; Neolignan; Suzuki-Miyaura reaction; Neurotrophic activity; CEREBRAL-ISCHEMIA-REPERFUSION; CONCISE SYNTHESIS; CELLS;

D O I：

10.1016/j.tetlet.2014.09.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient synthesis of honokiol (1) was accomplished using two kinds of Suzuki-Miyaura reactions. The first Suzuki-Miyaura reaction was employed to couple 2-bromophenol (6) with 4-hydroxyphenylboronic acid (5), giving rise to biphenol 4, and the second coupling was used to introduce allyl groups at 5- and 3'-positions of honokiol. The total synthesis of 1 was completed in 74% yield over five steps from 6, or in 83% yield over four steps from biphenol 4. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6001 / 6003

页数：3

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