Prediction of motivational impairment: 12-month follow-up of the randomized-controlled trial on extended early intervention for first-episode psychosis

Background: Amotivation is prevalent in first-episode psychosis ( FEP) patients and is a major determinant of functional outcome. Prediction of amotivation in the early stage of psychosis, however, is understudied. We aimed to prospectively examine predictors of amotivation in FEP patients in a randomizedcontrolled trial comparing a 1-year extension of early intervention ( Extended EI, 3-year EI) with stepdown psychiatric care ( SC, 2-year EI). Methods: One hundred sixty Chinese patents were recruited from a specialized EI program for FEP in Hong Kong after they have completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months. Assessments on premorbid adjustment, onset profiles, baseline symptom severity and treatment characteristics were conducted. Data analysis was based on 156 subjects who completed follow-up assessments. Results: Amotivation at 12-month follow-up was associated with premorbid adjustment, allocated treatment condition, and levels of positive symptoms, disorganization, amotivation, diminished expression ( DE) and depression at study intake. Hierarchical multiple regression analysis revealed that Extended EI and lower levels of DE independently predicted better outcome on 12-month amotivation. Conclusion: Our findings indicate a potentially critical therapeutic role of an extended specialized EI on alleviating motivational impairment in FEP patients. The longer-term effect of Extended EI on amotivation merits further investigation. (C) 2016 Elsevier Masson SAS. All rights reserved.