In-vitro dissolution and microbial inhibition studies on anticancer drug etoposide with β-cyclodextrin

被引：28

作者：

Arumugam, Shanmuga Priya ^{[1
]}

Balakrishnan, Suganya Bharathi ^{[1
]}

Ganesan, Vigneshkumar ^{[1
]}

Munisamy, Maniyazagan ^{[1
]}

Kuppu, Sakthi Velu ^{[1
]}

Narayanan, Vimalasruthi ^{[1
]}

Baskaralingam, Vaseeharan ^{[2
]}

Jeyachandran, Sivakamavalli ^{[2
]}

Thambusamy, Stalin ^{[1
]}

机构：

[1] Alagappa Univ, Sch Chem Sci, Dept Ind Chem, Karaikkudi 630003, Tamil Nadu, India

[2] Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 102卷

关键词：

Etoposide; beta-Cyclodextrin; Phase solubility; Dissolution rate; Antimicrobial efficacy; INCLUSION COMPLEX; PHOTOPHYSICAL PROPERTIES; 2,4-DINITROBENZOIC ACID; CHEMOSENSOR PROBE; UV ABSORBER; DELIVERY; SOLUBILITY; ANTITUMOR; RELEASE; PH;

D O I：

10.1016/j.msec.2019.04.033

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this article, we have reported the inclusion complex behaviors and their pharmaceutical application of anticancer drug property of Etoposide with beta-cyclodextrin. The inclusion complex is used to improve the poor aqueous solubility of the anticancer drug Etoposide. The aqueous solubility and in-vitro dissolution studies support to the anticancer drug Etoposide with beta-cyclodextrin complex is significantly improves the aqueous solubility. Etoposide: beta-cyclodextrin solid-state complexes were prepared by Physical mixture, kneading and solvent evaporation methods, and were characterized by FT-IR, (HNMR)-H-1, XRD, DSC and SEM techniques. In addition, the in-vitro antimicrobial and antibiofilm study of Etoposide drug is a sensible microorganism was significantly increased by an inclusion complexation process. The antibiofilm of anticancer drug Etoposide with ji-cyclodextrin studies have been analyzed by confocal laser scanning microscopy.

引用

页码：96 / 105

页数：10

共 59 条

[1] Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation [J].

Akasov, Roman ;

Borodina, Tatiana ;

Zaytseya, Ekaterina ;

Sumina, Anastasia ;

Bukreeva, Tatiana ;

Burov, Sergey ;

Markvicheya, Elena .

ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (30) :16581-16589

[2] A validated stability-indicating LC method for estimation of etoposide in bulk and optimized self-nano emulsifying formulation: Kinetics and stability effects [J].

Akhtar, Naseem ;

Talegaonkar, Sushama ;

Khar, Roop Kishan ;

Jaggi, Manu .

SAUDI PHARMACEUTICAL JOURNAL, 2013, 21 (01) :103-111

[3] Physicochemical properties of antifungal drug-cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques [J].

Al-Marzouqi, Ali H. ;

Elwy, Hanan M. ;

Shehadi, Ihsan ;

Adem, Abdu .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 49 (02) :227-233

[4] Complexation of enalapril maleate with β-cyclodextrin:: NMR spectroscopic study in solution [J].

Ali, Syed Mashhood ;

Maheshwari, Arti ;

Asmat, Fahmeena ;

Koketsu, Mamoru .

QUIMICA NOVA, 2006, 29 (04) :685-688

[5] Effects of hydroxypropyl-β-cyclodextrin on the chemical stability and the aqueous solubility of thalidomide enantiomers [J].

Alvarez, C. ;

Calero, J. ;

Menendez, J. C. ;

Torrado, S. ;

Torrado, J. J. .

PHARMAZIE, 2008, 63 (07) :511-513

[6]

[Anonymous], 2013, CANCER, V223, P101

[7] FRET-based Solid-state Luminescent Glyphosate Sensor Using Calixarene-grafted Ruthenium(II)bipyridine Doped Silica Nanoparticles [J].

Ashwin, Bosco Christin Maria Arputham ;

Saravanan, Chokalingam ;

Stalin, Thambusamy ;

Mareeswaran, Paulpandian Muthu ;

Rajagopal, Seenivasan .

CHEMPHYSCHEM, 2018, 19 (20) :2768-2775

[8]

ASO Y, 1989, CHEM PHARM BULL, V37, P2786

[9] Improvement of the in vitro dissolution of praziquantel by complexation with α-, β- and γ-cyclodextrins [J].

Becket, G ;

Schep, LJ ;

Tan, MY .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 179 (01) :65-71

[10] Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility-Permeability Interplay [J].

Beig, Avital ;

Miller, Jonathan M. ;

Lindley, David ;

Carr, Robert A. ;

Zocharski, Philip ;

Agbaria, Riad ;

Dahan, Arik .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (09) :2941-2947

← 1 2 3 4 5 6 →