Carbon nanomaterials as electrode surface modifiers in development of amperometric monoamino oxidase biosensors

被引:7
作者
Brusnitsyn, D. V. [1 ]
Medyantseva, E. P. [1 ]
Varlamova, R. M. [1 ]
Sitdikova, R. R. [1 ]
Fattakhova, A. N. [1 ]
Konovalova, O. A. [1 ]
Budnikov, G. K. [1 ]
机构
[1] Kazan Fed Univ, Kazan 420008, Russia
关键词
biosensors; monoamino oxidase; graphene oxide; carbon nanotubes; antidepressants; TRICYCLIC ANTIDEPRESSANTS; LIQUID-CHROMATOGRAPHY; NANOTUBES; CHITOSAN; ELECTROCHEMISTRY; NANOPARTICLES; GRAPHENE; FILMS;
D O I
10.1134/S002016851614003X
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Modification of a printed graphite electrode surface by carbon nanomaterials (carbon nanotubes and graphene oxide) was used to improve the analytical capabilities of amperometric monoamine oxidase biosensors in the determination of medicinal substances with antidepressant activity (moclobemide and amitriptyline). It was found that the range of determined concentrations of pharmaceutical agents varied from 1 x 10(-4) to 1 x 10(-8) mol/L. The developed monoamine oxidase biosensors were used for determination of medicinal agents in their dosage forms.
引用
收藏
页码:1413 / 1419
页数:7
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