Zinc-Catalyzed Cyclopropenation of Alkynes via 2-Furylcarbenoids

被引：51

作者：

Gonzalez, Maria J.

Lopez, Luis A. ^{[1
]}

Vicente, Ruben

机构：

[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 21期

关键词：

SOLID-STATE STRUCTURE; TERMINAL ALKYNES; CYCLOPROPANATION; INSERTION; FURAN; GENERATION; IZNCH2I;

D O I：

10.1021/ol502848n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented cyclopropenation reaction of alkynes catalyzed by ZnCl2 is reported. While SimmonsSmith-type carbenoids failed in the [2 + 1]-cycloaddition with alkynes, the use of enynones as the carbene source enables the preparation of substituted 2-furyl cyclopropene derivatives with remarkable scope.

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页码：5780 / 5783

页数：4

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